6U2J

EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex

Summary for 6U2J

• Entry DOI: 10.2210/pdb6u2j/pdb
• EMDB information: 20616 20617 20619 20620 20621 20622 20623
• Descriptor: Macrophage-expressed gene 1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: mpeg-1/perforin-2, macpf, macrophage, pore forming proteins, immunity, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 16
• Total formula weight: 1148348.11

Authors

Pang, S.S.,Bayly-Jones, C. (deposition date: 2019-08-20, release date: 2019-09-25, Last modification date: 2020-07-29)

• Primary citation: Pang, S.S.,Bayly-Jones, C.,Radjainia, M.,Spicer, B.A.,Law, R.H.P.,Hodel, A.W.,Parsons, E.S.,Ekkel, S.M.,Conroy, P.J.,Ramm, G.,Venugopal, H.,Bird, P.I.,Hoogenboom, B.W.,Voskoboinik, I.,Gambin, Y.,Sierecki, E.,Dunstone, M.A.,Whisstock, J.C.; The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.; Nat Commun, 10:4288-4288, 2019; PubMed: 31537793; DOI: 10.1038/s41467-019-12279-2

Experimental method

ELECTRON MICROSCOPY (2.37 Å)