2P1H
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![BU of 2p1h by Molmil](/molmil-images/mine/2p1h) | Rapid Folding and Unfolding of Apaf-1 CARD | Descriptor: | Apoptotic protease-activating factor 1, ZINC ION | Authors: | Milam, S.L, Nicely, N.I, Feeney, B, Mattos, C, Clark, A.C. | Deposit date: | 2007-03-05 | Release date: | 2007-05-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Rapid Folding and Unfolding of Apaf-1 CARD. J.Mol.Biol., 369, 2007
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3YGS
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![BU of 3ygs by Molmil](/molmil-images/mine/3ygs) | APAF-1 CARD IN COMPLEX WITH PRODOMAIN OF PROCASPASE-9 | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1, PROCASPASE 9 | Authors: | Qin, H, Srinivasula, S, Wu, G, Fernandes-Alnemri, T, Alnemri, E, Shi, Y. | Deposit date: | 1999-05-08 | Release date: | 2000-04-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature, 399, 1999
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4E9M
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![BU of 4e9m by Molmil](/molmil-images/mine/4e9m) | |
4UZ0
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![BU of 4uz0 by Molmil](/molmil-images/mine/4uz0) | Crystal Structure of apoptosis repressor with CARD (ARC) | Descriptor: | GLYCEROL, NUCLEOLAR PROTEIN 3 | Authors: | Kim, S.H, Jeong, J.H, Jang, T.H, Kim, Y.G, Park, H.H. | Deposit date: | 2014-09-04 | Release date: | 2015-07-01 | Last modified: | 2017-07-12 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Crystal Structure of Caspase Recruiting Domain (Card) of Apoptosis Repressor with Card (Arc) and its Implication in Inhibition of Apoptosis. Sci.Rep., 5, 2015
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6XKK
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![BU of 6xkk by Molmil](/molmil-images/mine/6xkk) | Cryo-EM structure of the NLRP1-CARD filament | Descriptor: | NACHT, LRR and PYD domains-containing protein 1 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | Deposit date: | 2020-06-26 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
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4RHW
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![BU of 4rhw by Molmil](/molmil-images/mine/4rhw) | Crystal structure of Apaf-1 CARD and caspase-9 CARD complex | Descriptor: | Apoptotic protease-activating factor 1, CHLORIDE ION, Caspase-9, ... | Authors: | Hu, Q, Wu, D, Yan, C, Shi, Y. | Deposit date: | 2014-10-03 | Release date: | 2014-10-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proc. Natl. Acad. Sci. U.S.A., 111, 2014
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8XQK
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![BU of 8xqk by Molmil](/molmil-images/mine/8xqk) | The Crystal Structure of Apaf from Biortus. | Descriptor: | Apoptotic protease-activating factor 1, PHOSPHATE ION | Authors: | Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C. | Deposit date: | 2024-01-05 | Release date: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The Crystal Structure of Apaf from Biortus. To Be Published
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3CRD
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![BU of 3crd by Molmil](/molmil-images/mine/3crd) | NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES | Descriptor: | RAIDD | Authors: | Chou, J.J, Matsuo, H, Duan, H, Wagner, G. | Deposit date: | 1998-07-24 | Release date: | 1999-02-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell(Cambridge,Mass.), 94, 1998
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6BZE
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![BU of 6bze by Molmil](/molmil-images/mine/6bze) | Cryo-EM structure of BCL10 CARD filament | Descriptor: | B-cell lymphoma/leukemia 10 | Authors: | David, L, Li, Y, Ma, J, Garner, E, Zhang, X, Wu, H. | Deposit date: | 2017-12-23 | Release date: | 2018-02-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2YGS
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![BU of 2ygs by Molmil](/molmil-images/mine/2ygs) | CARD DOMAIN FROM APAF-1 | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | Authors: | Shi, Y. | Deposit date: | 1999-05-08 | Release date: | 2000-04-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature, 399, 1999
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6E27
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![BU of 6e27 by Molmil](/molmil-images/mine/6e27) | The CARD9 CARD domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites | Descriptor: | Caspase recruitment domain-containing protein 9, ZINC ION | Authors: | Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J. | Deposit date: | 2018-07-10 | Release date: | 2018-09-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.811 Å) | Cite: | Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9. J. Biol. Chem., 293, 2018
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6E28
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![BU of 6e28 by Molmil](/molmil-images/mine/6e28) | The CARD9 CARD domain-swapped dimer | Descriptor: | Caspase recruitment domain-containing protein 9 | Authors: | Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J. | Deposit date: | 2018-07-10 | Release date: | 2018-09-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9. J. Biol. Chem., 293, 2018
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8CZO
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![BU of 8czo by Molmil](/molmil-images/mine/8czo) | Cryo-EM structure of BCL10 CARD - MALT1 DD filament | Descriptor: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | David, L, Wu, H. | Deposit date: | 2022-05-25 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. Cancer Discov, 12, 2022
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8CZD
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![BU of 8czd by Molmil](/molmil-images/mine/8czd) | Cryo-EM structure of BCL10 R58Q filament | Descriptor: | B-cell lymphoma/leukemia 10 | Authors: | David, L, Wu, H. | Deposit date: | 2022-05-24 | Release date: | 2022-06-22 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. Cancer Discov, 12, 2022
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7KEU
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![BU of 7keu by Molmil](/molmil-images/mine/7keu) | Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer | Descriptor: | Apoptosis-associated speck-like protein containing a CARD, Caspase-1 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Ruan, J, Wu, H. | Deposit date: | 2020-10-12 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
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5YRN
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![BU of 5yrn by Molmil](/molmil-images/mine/5yrn) | Structure of RIP2 CARD domain | Descriptor: | Receptor-interacting serine/threonine-protein kinase 2 | Authors: | Wu, B, Gong, Q. | Deposit date: | 2017-11-09 | Release date: | 2018-11-14 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of RIP2 activation and signaling. Nat Commun, 9, 2018
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5WVC
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![BU of 5wvc by Molmil](/molmil-images/mine/5wvc) | Structure of the CARD-CARD disk | Descriptor: | Apoptotic protease-activating factor 1, Caspase, IODIDE ION | Authors: | Lin, S.C, Lo, Y.C, Su, T.W. | Deposit date: | 2016-12-24 | Release date: | 2017-04-19 | Method: | X-RAY DIFFRACTION (2.993 Å) | Cite: | Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome. Structure, 25, 2017
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3KAT
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![BU of 3kat by Molmil](/molmil-images/mine/3kat) | Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E | Descriptor: | NACHT, LRR and PYD domains-containing protein 1 | Authors: | Forouhar, F, Abashidze, M, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Shastry, R, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-10-19 | Release date: | 2009-10-27 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Northeast Structural Genomics Consortium Target HR3486E To be Published
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5H8O
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![BU of 5h8o by Molmil](/molmil-images/mine/5h8o) | Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC | Descriptor: | Apoptosis-associated speck-like protein containing a CARD, VHH nanobody | Authors: | Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L. | Deposit date: | 2015-12-23 | Release date: | 2016-04-06 | Last modified: | 2016-05-18 | Method: | X-RAY DIFFRACTION (4.206 Å) | Cite: | A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J.Exp.Med., 213, 2016
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6XKJ
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![BU of 6xkj by Molmil](/molmil-images/mine/6xkj) | Cryo-EM structure of CARD8-CARD filament | Descriptor: | Caspase recruitment domain-containing protein 8 | Authors: | Hollingsworth, L.R, David, L, Li, Y, Sharif, H, Fontana, P, Fu, T, Wu, H. | Deposit date: | 2020-06-26 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun, 12, 2021
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5FNA
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![BU of 5fna by Molmil](/molmil-images/mine/5fna) | Cryo-EM reconstruction of caspase-1 CARD | Descriptor: | Caspase-1 | Authors: | Li, Y, Lu, A, Schmidt, F.I, Yin, Q, Chen, S, Fu, T.M, Tong, A.B, Ploegh, H.L, Mao, Y, Wu, H. | Deposit date: | 2015-11-11 | Release date: | 2016-03-30 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism Nat.Struct.Mol.Biol., 23, 2016
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1C15
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![BU of 1c15 by Molmil](/molmil-images/mine/1c15) | SOLUTION STRUCTURE OF APAF-1 CARD | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | Authors: | Zhou, P, Chou, J, Olea, R.S, Yuan, J, Wagner, G. | Deposit date: | 1999-07-20 | Release date: | 1999-09-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction. Proc.Natl.Acad.Sci.USA, 96, 1999
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1DGN
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![BU of 1dgn by Molmil](/molmil-images/mine/1dgn) | SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION | Descriptor: | ICEBERG (PROTEASE INHIBITOR) | Authors: | Humke, E.W, Shriver, S.K, Starovasnik, M.A, Fairbrother, W.J, Dixit, V.M. | Deposit date: | 1999-11-24 | Release date: | 2000-10-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell(Cambridge,Mass.), 103, 2000
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2B1W
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1CWW
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![BU of 1cww by Molmil](/molmil-images/mine/1cww) | SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1 | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | Authors: | Day, C.L, Dupont, C, Lackmann, M, Vaux, D.L, Hinds, M.G. | Deposit date: | 1999-08-26 | Release date: | 2000-01-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1. Cell Death Differ., 6, 1999
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