5H8O
Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC
Summary for 5H8O
Entry DOI | 10.2210/pdb5h8o/pdb |
Related | 5H8D |
Descriptor | VHH nanobody, Apoptosis-associated speck-like protein containing a CARD (2 entities in total) |
Functional Keywords | vhh nanobody, asc-binding, antibody fragment, inflammasome, immune system |
Biological source | Lama glama (llama) More |
Cellular location | Cytoplasm: Q9ULZ3 |
Total number of polymer chains | 2 |
Total formula weight | 21717.33 |
Authors | Lu, A.,Schmidt, F.I.,Ruan, J.,Tang, C.,Wu, H.,Ploegh, H.L. (deposition date: 2015-12-23, release date: 2016-04-06, Last modification date: 2016-05-18) |
Primary citation | Schmidt, F.I.,Lu, A.,Chen, J.W.,Ruan, J.,Tang, C.,Wu, H.,Ploegh, H.L. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J.Exp.Med., 213:771-790, 2016 Cited by PubMed: 27069117DOI: 10.1084/jem.20151790 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.206 Å) |
Structure validation
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