5FNA

Cryo-EM reconstruction of caspase-1 CARD

Summary for 5FNA

• Entry DOI: 10.2210/pdb5fna/pdb
• EMDB information: 3241
• Descriptor: Caspase-1 (1 entity in total)
• Functional Keywords: hydrolase, card, inflammasome, filament, signalosome, helical reconstruction, death domain
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 76721.37

Authors

Li, Y.,Lu, A.,Schmidt, F.I.,Yin, Q.,Chen, S.,Fu, T.M.,Tong, A.B.,Ploegh, H.L.,Mao, Y.,Wu, H. (deposition date: 2015-11-11, release date: 2016-03-30, Last modification date: 2019-09-11)

• Primary citation: Li, Y.,Lu, A.,Schmidt, F.I.,Yin, Q.,Chen, S.,Fu, T.M.,Tong, A.B.,Ploegh, H.L.,Mao, Y.,Wu, H.; Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism; Nat.Struct.Mol.Biol., 23:416-, 2016; PubMed: 27043298; DOI: 10.1038/NSMB.3199

Experimental method

ELECTRON MICROSCOPY (4.8 Å)