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PDB: 189 results

3F80
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(S)-2-amino-6-nitrohexanoic acid binds to human arginase I through multiple nitro-metal coordination interactions in the binuclear manganese cluster. Resolution 1.60 A.
Descriptor: 6-nitro-L-norleucine, Arginase-1, MANGANESE (II) ION
Authors:Di Costanzo, L, Christianson, D.W.
Deposit date:2008-11-10
Release date:2008-12-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:(S)-2-Amino-6-nitrohexanoic Acid Binds to Human Arginase I through Multiple Nitro-Metal Coordination Interactions in the Binuclear Manganese Cluster.
J.Am.Chem.Soc., 130, 2008
1P8N
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Structural and Functional Importance of First-Shell Metal Ligands in the Binuclear Manganese Cluster of Arginase I.
Descriptor: Arginase 1, GLYCEROL, MANGANESE (II) ION
Authors:Cama, E, Emig, F.A, Ash, D.E, Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
1P8O
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Structural and Functional Importance of First-Shell Metal Ligands in the Binuclear Manganese Cluster of Arginase I.
Descriptor: Arginase 1, MANGANESE (II) ION
Authors:Cama, E, Emig, F.A, Ash, D.E, Christianson, D.W.
Deposit date:2003-05-07
Release date:2003-06-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
Biochemistry, 42, 2003
7KLK
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Human Arginase1 Complexed with Inhibitor Compound 3a
Descriptor: 1,2-ETHANEDIOL, 3-[(2~{S},3~{R})-2-carboxypiperidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, Arginase-1, ...
Authors:Palte, R.L.
Deposit date:2020-10-30
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Acs Med.Chem.Lett., 12, 2021
7KLM
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Human Arginase1 Complexed with Inhibitor Compound 24a
Descriptor: 3-[(2~{S},3~{R},4~{R})-4-[[(2~{S})-2-azanyl-3-methyl-butanoyl]amino]-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, MANGANESE (II) ION
Authors:Palte, R.L.
Deposit date:2020-10-30
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Acs Med.Chem.Lett., 12, 2021
7KLL
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BU of 7kll by Molmil
Human Arginase1 Complexed with Inhibitor Compound 18
Descriptor: 3-[(2~{S},3~{R},4~{R})-4-azanyl-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, Arginase-1, MANGANESE (II) ION
Authors:Palte, R.L.
Deposit date:2020-10-30
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Acs Med.Chem.Lett., 12, 2021
3DJ8
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BU of 3dj8 by Molmil
Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I
Descriptor: 6-[(2R)-oxiran-2-yl]-L-norleucine, Arginase-1, MANGANESE (II) ION
Authors:Di Costanzo, L, Christianson, D.W.
Deposit date:2008-06-22
Release date:2008-07-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I
Org.Biomol.Chem., 6, 2008
4ITY
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BU of 4ity by Molmil
Crystal structure of Leishmania mexicana arginase
Descriptor: Arginase, GLYCEROL, MANGANESE (II) ION
Authors:D'Antonio, E.L, Ullman, B, Roberts, S.C, Gaur Dixit, U, Wilson, M.E, Hai, Y, Christianson, D.W.
Deposit date:2013-01-19
Release date:2013-01-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
Arch.Biochem.Biophys., 535, 2013
4IXU
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BU of 4ixu by Molmil
Crystal structure of human Arginase-2 complexed with inhibitor 11d: {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
Descriptor: Arginase-2, mitochondrial, BENZAMIDINE, ...
Authors:Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D, Beckett, P, Van Zandt, M.C, Ji, M.K, Ryder, T, Jagdmann, R, Andreoli, M, Olczak, J, Mazur, M, Czestkowski, W, Piotrowska, W, Schroeter, H, Golebiowski, A, Podjarny, A.
Deposit date:2013-01-28
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
Bioorg.Med.Chem.Lett., 23, 2013
7LBA
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BU of 7lba by Molmil
E. coli Agmatinase
Descriptor: Agmatinase, MANGANESE (II) ION
Authors:Chitrakar, I, Ahmed, S.F, Torelli, A.T, French, J.B.
Deposit date:2021-01-07
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the E. coli agmatinase, SPEB.
Plos One, 16, 2021
4IU4
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BU of 4iu4 by Molmil
Crystal structure of Leishmania mexicana arginase in complex with inhibitor BEC
Descriptor: Arginase, BETA-MERCAPTOETHANOL, GLYCEROL, ...
Authors:D'Antonio, E.L, Ullman, B, Roberts, S.C, Gaur Dixit, U, Wilson, M.E, Hai, Y, Christianson, D.W.
Deposit date:2013-01-19
Release date:2013-01-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
Arch.Biochem.Biophys., 535, 2013
4IU1
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BU of 4iu1 by Molmil
Crystal structure of Leishmania mexicana arginase in complex with inhibitor nor-NOHA
Descriptor: Arginase, GLYCEROL, MANGANESE (II) ION, ...
Authors:D'Antonio, E.L, Ullman, B, Roberts, S.C, Gaur Dixit, U, Wilson, M.E, Hai, Y, Christianson, D.W.
Deposit date:2013-01-19
Release date:2013-01-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
Arch.Biochem.Biophys., 535, 2013
7LOL
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BU of 7lol by Molmil
The structure of Agmatinase from E. Coli at 1.8 A displaying urea and agmatine
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AGMATINE, Agmatinase, ...
Authors:Maturana, P, Figueroa, M, Gonzalez-Ordenes, F, Villalobos, P, Martinez-Oyanedel, J, Uribe, E.A, Castro-Fernandez, V.
Deposit date:2021-02-10
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Escherichia coli Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity.
Int J Mol Sci, 22, 2021
7LOX
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BU of 7lox by Molmil
The structure of Agmatinase from E. Coli at 3.2 A displaying guanidine in the active site
Descriptor: Agmatinase, GUANIDINE, MANGANESE (II) ION
Authors:Maturana, P, Figueroa, M, Gonzalez-Ordenes, F, Villalobos, P, Martinez-Oyanedel, J, Uribe, E.A, Castro-Fernandez, V.
Deposit date:2021-02-11
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of Escherichia coli Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity.
Int J Mol Sci, 22, 2021
4IXV
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BU of 4ixv by Molmil
Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)
Descriptor: Arginase-2, mitochondrial, BENZAMIDINE, ...
Authors:Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Whitehouse, D, Beckett, P, Van Zandt, M.C, Ji, M.K, Ryder, T, Jagdmann, R, Andreoli, M, Olczak, J, Mazur, M, Czestkowski, W, Piotrowska, W, Schroeter, H, Golebiowski, A, Podjarny, A.
Deposit date:2013-01-28
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
Bioorg.Med.Chem.Lett., 23, 2013
7LEX
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BU of 7lex by Molmil
Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:3 mAb1 complex
Descriptor: Arginase-1, mAb1 heavy chain, mAb1 light chain
Authors:Gomez-Llorente, Y, Scapin, G, Palte, R.L.
Deposit date:2021-01-15
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LEZ
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BU of 7lez by Molmil
Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex
Descriptor: Arginase-1, MANGANESE (II) ION, mAb1 heavy chain, ...
Authors:Gomez-Llorente, Y, Scapin, G, Palte, R.L.
Deposit date:2021-01-15
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (4.15 Å)
Cite:Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LF1
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BU of 7lf1 by Molmil
Trimeric human Arginase 1 in complex with mAb3
Descriptor: Arginase-1, MANGANESE (II) ION, mAb3 heavy chain, ...
Authors:Gomez-Llorente, Y, Scapin, G, Palte, R.L.
Deposit date:2021-01-15
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (4.04 Å)
Cite:Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LEY
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BU of 7ley by Molmil
Trimeric human Arginase 1 in complex with mAb5
Descriptor: Arginase-1, MANGANESE (II) ION, mAb5 heavy chain, ...
Authors:Gomez-Llorente, Y, Scapin, G, Palte, R.L.
Deposit date:2021-01-15
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LF0
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BU of 7lf0 by Molmil
Trimeric human Arginase 1 in complex with mAb2
Descriptor: Arginase-1, mAb2 heavy chain, mAb2 light chain
Authors:Gomez-Llorente, Y, Scapin, G, Palte, R.L.
Deposit date:2021-01-15
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
7LF2
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BU of 7lf2 by Molmil
Trimeric human Arginase 1 in complex with mAb4
Descriptor: Arginase-1, MANGANESE (II) ION, mAb4 monoclonal antibody heavy chain, ...
Authors:Gomez-Llorente, Y, Scapin, G, Palte, R.L.
Deposit date:2021-01-15
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
4IU0
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BU of 4iu0 by Molmil
Crystal structure of Leishmania mexicana arginase in complex with inhibitor ABH
Descriptor: 2(S)-AMINO-6-BORONOHEXANOIC ACID, Arginase, GLYCEROL, ...
Authors:D'Antonio, E.L, Ullman, B, Roberts, S.C, Gaur Dixit, U, Wilson, M.E, Hai, Y, Christianson, D.W.
Deposit date:2013-01-19
Release date:2013-01-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.
Arch.Biochem.Biophys., 535, 2013
4MYL
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BU of 4myl by Molmil
Crystal structure of Trypanosoma cruzi Formiminoglutamase (oxidized) at pH 4.6
Descriptor: Formiminoglutamase
Authors:Hai, Y, Dugery, R.J, Healy, D, Christianson, D.W.
Deposit date:2013-09-27
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.531 Å)
Cite:Formiminoglutamase from trypanosoma cruzi is an arginase-like manganese metalloenzyme.
Biochemistry, 52, 2013
4MYF
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BU of 4myf by Molmil
Crystal structure of Trypanosoma cruzi formiminoglutamase(oxidized) with Mn2+2 at pH 6.0
Descriptor: Formiminoglutamase, MANGANESE (II) ION
Authors:Hai, Y, Dugery, R.J, Healy, D, Christianson, D.W.
Deposit date:2013-09-27
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Formiminoglutamase from trypanosoma cruzi is an arginase-like manganese metalloenzyme.
Biochemistry, 52, 2013
4MYK
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BU of 4myk by Molmil
Crystal structure of Trypanosoma cruzi formiminoglutamase (oxidized) with Mn2+2 at pH 8.5
Descriptor: Formiminoglutamase, MANGANESE (II) ION
Authors:Hai, Y, Dugery, R.J, Healy, D, Christianson, D.W.
Deposit date:2013-09-27
Release date:2013-11-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.518 Å)
Cite:Formiminoglutamase from trypanosoma cruzi is an arginase-like manganese metalloenzyme.
Biochemistry, 52, 2013

221051

數據於2024-06-12公開中

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