7KLL
Human Arginase1 Complexed with Inhibitor Compound 18
Summary for 7KLL
Entry DOI | 10.2210/pdb7kll/pdb |
Descriptor | Arginase-1, MANGANESE (II) ION, 3-[(2~{S},3~{R},4~{R})-4-azanyl-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, ... (4 entities in total) |
Functional Keywords | arginase, hydrolase, urea cycle, metabolism, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 210736.83 |
Authors | Palte, R.L. (deposition date: 2020-10-30, release date: 2021-09-29, Last modification date: 2023-10-18) |
Primary citation | Lu, M.,Zhang, H.,Li, D.,Childers, M.,Pu, Q.,Palte, R.L.,Gathiaka, S.,Lyons, T.W.,Palani, A.,Fan, P.W.,Spacciapoli, P.,Miller, J.R.,Cho, H.,Cheng, M.,Chakravarthy, K.,O'Neil, J.,Eangoor, P.,Beard, A.,Kim, H.Y.,Sauri, J.,Gunaydin, H.,Sloman, D.L.,Siliphaivanh, P.,Cumming, J.,Fischer, C. Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. Acs Med.Chem.Lett., 12:1380-1388, 2021 Cited by PubMed: 34527178DOI: 10.1021/acsmedchemlett.1c00195 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.22 Å) |
Structure validation
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