7K4J

Human Arginase 1 in complex with compound 51.

Summary for 7K4J

• Entry DOI: 10.2210/pdb7k4j/pdb
• Descriptor: Arginase-1, MANGANESE (II) ION, 3-[(1~{S},2~{S},5~{R})-2-carboxy-3,6-diazabicyclo[3.2.0]heptan-1-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boranuide, ... (4 entities in total)
• Functional Keywords: arginase, hydrolase, arginine, urea cycle, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 210808.90

Authors

Palte, R.L. (deposition date: 2020-09-15, release date: 2021-12-01, Last modification date: 2023-10-18)

• Primary citation: Li, D.,Zhang, H.,Lyons, T.W.,Lu, M.,Achab, A.,Pu, Q.,Childers, M.,Mitcheltree, M.J.,Wang, J.,Martinot, T.A.,McMinn, S.E.,Sloman, D.L.,Palani, A.,Beard, A.,Nogle, L.,Gathiaka, S.,Sauri, J.,Kim, H.Y.,Adpressa, D.,Spacciapoli, P.,Miller, J.R.,Palte, R.L.,Lesburg, C.A.,Cumming, J.,Fischer, C.; Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.; Acs Med.Chem.Lett., 12:1678-1688, 2021; PubMed: 34795856; DOI: 10.1021/acsmedchemlett.1c00258

Experimental method

X-RAY DIFFRACTION (1.94 Å)