7LF2

Trimeric human Arginase 1 in complex with mAb4

Summary for 7LF2

• Entry DOI: 10.2210/pdb7lf2/pdb
• EMDB information: 23298
• Descriptor: Arginase-1, mAb4 monoclonal antibody heavy chain, mAb4 monoclonal antibody light chain, ... (4 entities in total)
• Functional Keywords: arginase, metalloenzyme, immune system, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 18
• Total formula weight: 643431.71

Authors

Gomez-Llorente, Y.,Scapin, G.,Palte, R.L. (deposition date: 2021-01-15, release date: 2021-09-01)

• Primary citation: Palte, R.L.,Juan, V.,Gomez-Llorente, Y.,Bailly, M.A.,Chakravarthy, K.,Chen, X.,Cipriano, D.,Fayadat-Dilman, L.,Gathiaka, S.,Greb, H.,Hall, B.,Handa, M.,Hsieh, M.,Kofman, E.,Lin, H.,Miller, J.R.,Nguyen, N.,O'Neil, J.,Shaheen, H.,Sterner, E.,Strickland, C.,Sun, A.,Taremi, S.,Scapin, G.; Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.; Commun Biol, 4:927-927, 2021; PubMed: 34326456; DOI: 10.1038/s42003-021-02444-z

Experimental method

ELECTRON MICROSCOPY (3.72 Å)