7LF2

Trimeric human Arginase 1 in complex with mAb4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0004053	molecular_function	arginase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006525	biological_process	arginine metabolic process
A	0006527	biological_process	L-arginine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0030145	molecular_function	manganese ion binding
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042127	biological_process	regulation of cell population proliferation
A	0042130	biological_process	negative regulation of T cell proliferation
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
A	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
B	0000050	biological_process	urea cycle
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0004053	molecular_function	arginase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006525	biological_process	arginine metabolic process
B	0006527	biological_process	L-arginine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0030145	molecular_function	manganese ion binding
B	0035578	cellular_component	azurophil granule lumen
B	0035580	cellular_component	specific granule lumen
B	0042127	biological_process	regulation of cell population proliferation
B	0042130	biological_process	negative regulation of T cell proliferation
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
B	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
B	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
C	0000050	biological_process	urea cycle
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0004053	molecular_function	arginase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006525	biological_process	arginine metabolic process
C	0006527	biological_process	L-arginine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0030145	molecular_function	manganese ion binding
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042127	biological_process	regulation of cell population proliferation
C	0042130	biological_process	negative regulation of T cell proliferation
C	0042832	biological_process	defense response to protozoan
C	0045087	biological_process	innate immune response
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
C	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
C	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
J	0000050	biological_process	urea cycle
J	0002250	biological_process	adaptive immune response
J	0002376	biological_process	immune system process
J	0004053	molecular_function	arginase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006525	biological_process	arginine metabolic process
J	0006527	biological_process	L-arginine catabolic process
J	0016787	molecular_function	hydrolase activity
J	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
J	0030145	molecular_function	manganese ion binding
J	0035578	cellular_component	azurophil granule lumen
J	0035580	cellular_component	specific granule lumen
J	0042127	biological_process	regulation of cell population proliferation
J	0042130	biological_process	negative regulation of T cell proliferation
J	0042832	biological_process	defense response to protozoan
J	0045087	biological_process	innate immune response
J	0046007	biological_process	negative regulation of activated T cell proliferation
J	0046872	molecular_function	metal ion binding
J	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
J	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
J	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
Q	0000050	biological_process	urea cycle
Q	0002250	biological_process	adaptive immune response
Q	0002376	biological_process	immune system process
Q	0004053	molecular_function	arginase activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006525	biological_process	arginine metabolic process
Q	0006527	biological_process	L-arginine catabolic process
Q	0016787	molecular_function	hydrolase activity
Q	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Q	0030145	molecular_function	manganese ion binding
Q	0035578	cellular_component	azurophil granule lumen
Q	0035580	cellular_component	specific granule lumen
Q	0042127	biological_process	regulation of cell population proliferation
Q	0042130	biological_process	negative regulation of T cell proliferation
Q	0042832	biological_process	defense response to protozoan
Q	0045087	biological_process	innate immune response
Q	0046007	biological_process	negative regulation of activated T cell proliferation
Q	0046872	molecular_function	metal ion binding
Q	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
Q	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
Q	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
R	0000050	biological_process	urea cycle
R	0002250	biological_process	adaptive immune response
R	0002376	biological_process	immune system process
R	0004053	molecular_function	arginase activity
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006525	biological_process	arginine metabolic process
R	0006527	biological_process	L-arginine catabolic process
R	0016787	molecular_function	hydrolase activity
R	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
R	0030145	molecular_function	manganese ion binding
R	0035578	cellular_component	azurophil granule lumen
R	0035580	cellular_component	specific granule lumen
R	0042127	biological_process	regulation of cell population proliferation
R	0042130	biological_process	negative regulation of T cell proliferation
R	0042832	biological_process	defense response to protozoan
R	0045087	biological_process	innate immune response
R	0046007	biological_process	negative regulation of activated T cell proliferation
R	0046872	molecular_function	metal ion binding
R	0060336	biological_process	negative regulation of type II interferon-mediated signaling pathway
R	0070965	biological_process	positive regulation of neutrophil mediated killing of fungus
R	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH

Chain	Residue	Details
D	TYR197-HIS203
D	PHE419-HIS425
E	TYR192-HIS198

---

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDVDgldPsftPAtgtpvvgG

Chain	Residue	Details
A	SER230-GLY251

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16141327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17469833","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17562323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18802628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21728378","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WVA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WVB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3E6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SKK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GSZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PDB","id":"3GMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P53608","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P78540","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q61176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---