3SL1
Crystal Structure of P. falciparum arginase complexed with 2-amino-6-borono-2-methylhexanoic acid
Summary for 3SL1
Entry DOI | 10.2210/pdb3sl1/pdb |
Related | 3GMZ 3GN0 3MMR 3SJT 3SKK 3SL0 |
Descriptor | Arginase, MANGANESE (II) ION, 6-(dihydroxyboranyl)-2-methyl-L-norleucine, ... (4 entities in total) |
Functional Keywords | metallohydrolase, arginase fold, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 1 |
Total formula weight | 46750.93 |
Authors | Dowling, D.P.,Ilies, M.,Christianson, D.W. (deposition date: 2011-06-23, release date: 2011-07-20, Last modification date: 2023-09-13) |
Primary citation | Ilies, M.,Di Costanzo, L.,Dowling, D.P.,Thorn, K.J.,Christianson, D.W. Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J.Med.Chem., 54:5432-5443, 2011 Cited by PubMed: 21728378DOI: 10.1021/jm200443b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.902 Å) |
Structure validation
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