3SJT
Crystal structure of human arginase I in complex with the inhibitor Me-ABH, Resolution 1.60 A, twinned structure
Summary for 3SJT
| Entry DOI | 10.2210/pdb3sjt/pdb |
| Related | 2AEB 3GMZ 3GN0 3SKK 3SL0 3SL1 |
| Descriptor | Arginase-1, MANGANESE (II) ION, [(5S)-5-amino-5-carboxyhexyl](trihydroxy)borate, ... (4 entities in total) |
| Functional Keywords | hydrolase, abh inhibitor derivative, twinning, 2-amino-6-borono-2-methylhexanoic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P05089 |
| Total number of polymer chains | 2 |
| Total formula weight | 70191.56 |
| Authors | Di Costanzo, L.,Christianson, D.W. (deposition date: 2011-06-21, release date: 2011-07-20, Last modification date: 2023-09-13) |
| Primary citation | Ilies, M.,Di Costanzo, L.,Dowling, D.P.,Thorn, K.J.,Christianson, D.W. Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J.Med.Chem., 54:5432-5443, 2011 Cited by PubMed: 21728378DOI: 10.1021/jm200443b PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.597 Å) |
Structure validation
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