3SKK
Crystal structure of human arginase I in complex with the inhibitor FABH, Resolution 1.70 A, twinned structure
Summary for 3SKK
| Entry DOI | 10.2210/pdb3skk/pdb |
| Related | 2AEB 3GMZ 3GN0 3SJT 3SL0 3SL1 |
| Descriptor | Arginase-1, MANGANESE (II) ION, [(5S)-5-amino-5-carboxy-6,6-difluorohexyl](trihydroxy)borate(1-), ... (4 entities in total) |
| Functional Keywords | abh inhibitor derivative, twinning, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P05089 |
| Total number of polymer chains | 2 |
| Total formula weight | 70263.52 |
| Authors | Thorn, K.J.,Di Costanzo, L.,Christianson, D.W. (deposition date: 2011-06-22, release date: 2011-07-20, Last modification date: 2023-09-13) |
| Primary citation | Ilies, M.,Di Costanzo, L.,Dowling, D.P.,Thorn, K.J.,Christianson, D.W. Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J.Med.Chem., 54:5432-5443, 2011 Cited by PubMed: 21728378DOI: 10.1021/jm200443b PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.701 Å) |
Structure validation
Download full validation report
