7KLM

Human Arginase1 Complexed with Inhibitor Compound 24a

Summary for 7KLM

• Entry DOI: 10.2210/pdb7klm/pdb
• Descriptor: Arginase-1, MANGANESE (II) ION, 3-[(2~{S},3~{R},4~{R})-4-[[(2~{S})-2-azanyl-3-methyl-butanoyl]amino]-2-carboxy-pyrrolidin-3-yl]propyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, ... (4 entities in total)
• Functional Keywords: arginase, hydrolase, urea cycle, metabolism, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 211331.62

Authors

Palte, R.L. (deposition date: 2020-10-30, release date: 2021-09-29, Last modification date: 2023-10-18)

• Primary citation: Lu, M.,Zhang, H.,Li, D.,Childers, M.,Pu, Q.,Palte, R.L.,Gathiaka, S.,Lyons, T.W.,Palani, A.,Fan, P.W.,Spacciapoli, P.,Miller, J.R.,Cho, H.,Cheng, M.,Chakravarthy, K.,O'Neil, J.,Eangoor, P.,Beard, A.,Kim, H.Y.,Sauri, J.,Gunaydin, H.,Sloman, D.L.,Siliphaivanh, P.,Cumming, J.,Fischer, C.; Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.; Acs Med.Chem.Lett., 12:1380-1388, 2021; PubMed: 34527178; DOI: 10.1021/acsmedchemlett.1c00195

Experimental method

X-RAY DIFFRACTION (2.27 Å)