9B4H
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![BU of 9b4h by Molmil](/molmil-images/mine/9b4h) | Chlamydomonas reinhardtii mastigoneme filament | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain-containing protein, Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein, ... | Authors: | Dai, J, Ma, M, Zhang, R, Brown, A. | Deposit date: | 2024-03-20 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices. Cell, 2024
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6RN4
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6S4L
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![BU of 6s4l by Molmil](/molmil-images/mine/6s4l) | Structure of human KCTD1 | Descriptor: | BTB/POZ domain-containing protein KCTD1, IODIDE ION, SODIUM ION | Authors: | Pinkas, D.M, Bufton, J.C, Fox, A.E, Pike, A.C.W, Newman, J.A, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Bullock, A.N. | Deposit date: | 2019-06-28 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Structure of human KCTD1 To be published
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6S9W
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6S9X
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![BU of 6s9x by Molmil](/molmil-images/mine/6s9x) | Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 15c | Descriptor: | RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-[(4-hydroxyphenyl)methyl]-6-oxidanylidene-2-phenyl-1~{H}-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide | Authors: | Landel, I, Mueller, M.P, Rauh, D. | Deposit date: | 2019-07-15 | Release date: | 2019-10-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019
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7TE6
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![BU of 7te6 by Molmil](/molmil-images/mine/7te6) | Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody | Descriptor: | Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ... | Authors: | Regan, M, Tajima, N, Furukawa, H. | Deposit date: | 2022-01-04 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (4.55 Å) | Cite: | Development and characterization of functional antibodies targeting NMDA receptors. Nat Commun, 13, 2022
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6RN2
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6RN3
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6M8S
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![BU of 6m8s by Molmil](/molmil-images/mine/6m8s) | Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits | Descriptor: | BTB/POZ domain-containing protein KCTD12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Authors: | Zheng, S, Kruse, A.C. | Deposit date: | 2018-08-22 | Release date: | 2019-02-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.71 Å) | Cite: | Structural basis for KCTD-mediated rapid desensitization of GABABsignalling. Nature, 567, 2019
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7KSL
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![BU of 7ksl by Molmil](/molmil-images/mine/7ksl) | Substrate-free human mitochondrial LONP1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | Deposit date: | 2020-11-23 | Release date: | 2020-12-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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7KSM
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![BU of 7ksm by Molmil](/molmil-images/mine/7ksm) | Human mitochondrial LONP1 with endogenous substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | Deposit date: | 2020-11-23 | Release date: | 2020-12-02 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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7KRZ
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![BU of 7krz by Molmil](/molmil-images/mine/7krz) | Human mitochondrial LONP1 in complex with Bortezomib | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ... | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | Deposit date: | 2020-11-20 | Release date: | 2021-02-24 | Last modified: | 2022-06-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nat Commun, 12, 2021
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6QB7
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![BU of 6qb7 by Molmil](/molmil-images/mine/6qb7) | Structure of the H1 domain of human KCTD16 | Descriptor: | BTB/POZ domain-containing protein KCTD16, PHOSPHATE ION | Authors: | Pinkas, D.M, Bufton, J.C, Williams, E.P, Strain-Damerell, C, Kupinska, K, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2018-12-20 | Release date: | 2019-02-06 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Structure of the H1 domain of human KCTD16 To be published
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7LCU
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![BU of 7lcu by Molmil](/molmil-images/mine/7lcu) | X-ray structure of Furin bound to BOS-318, a small molecule inhibitor | Descriptor: | (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Campobasso, N, Reid, R. | Deposit date: | 2021-01-11 | Release date: | 2022-01-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease. Cell Chem Biol, 29, 2022
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6QS8
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6QS7
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6QS6
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6QS4
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4CP4
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4WVM
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![BU of 4wvm by Molmil](/molmil-images/mine/4wvm) | Stonustoxin structure | Descriptor: | Stonustoxin subunit alpha, Stonustoxin subunit beta | Authors: | Ellisdon, A.M, Panjikar, S, Whisstock, J.C, McGowan, S. | Deposit date: | 2014-11-06 | Release date: | 2015-12-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Stonefish toxin defines an ancient branch of the perforin-like superfamily. Proc.Natl.Acad.Sci.USA, 112, 2015
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5FQD
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![BU of 5fqd by Molmil](/molmil-images/mine/5fqd) | Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase | Descriptor: | CASEIN KINASE I ISOFORM ALPHA, DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ... | Authors: | Petzold, G, Fischer, E.S, Thoma, N.H. | Deposit date: | 2015-12-09 | Release date: | 2016-02-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase. Nature, 532, 2016
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4CHL
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![BU of 4chl by Molmil](/molmil-images/mine/4chl) | Human Ethylmalonic Encephalopathy Protein 1 (hETHE1) | Descriptor: | FE (III) ION, PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL | Authors: | Pettinati, I, Brem, J, McDonough, M.A, Schofield, C.J. | Deposit date: | 2013-12-03 | Release date: | 2014-12-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. Hum. Mol. Genet., 24, 2015
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5HXB
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![BU of 5hxb by Molmil](/molmil-images/mine/5hxb) | Cereblon in complex with DDB1, CC-885, and GSPT1 | Descriptor: | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | Authors: | Chamberlain, P.P, Matyskiela, M, Pagarigan, B. | Deposit date: | 2016-01-30 | Release date: | 2016-06-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature, 535, 2016
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5GIP
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![BU of 5gip by Molmil](/molmil-images/mine/5gip) | Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates | Descriptor: | 50S ribosomal protein L7Ae, C/D RNA, C/D box methylation guide ribonucleoprotein complex aNOP56 subunit, ... | Authors: | Yang, Z, Lin, J, Ye, K. | Deposit date: | 2016-06-24 | Release date: | 2016-09-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.129 Å) | Cite: | Box C/D guide RNAs recognize a maximum of 10 nt of substrates Proc.Natl.Acad.Sci.USA, 113, 2016
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4B8X
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![BU of 4b8x by Molmil](/molmil-images/mine/4b8x) | Near atomic resolution crystal structure of Sco5413, a MarR family transcriptional regulator from Streptomyces coelicolor | Descriptor: | CHLORIDE ION, POSSIBLE MARR-TRANSCRIPTIONAL REGULATOR | Authors: | Holley, T.A, Stevenson, C.E.M, Bibb, M.J, Lawson, D.M. | Deposit date: | 2012-08-31 | Release date: | 2012-10-17 | Last modified: | 2019-05-22 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | High Resolution Crystal Structure of Sco5413, a Widespread Actinomycete Marr Family Transcriptional Regulator of Unknown Function. Proteins, 81, 2013
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