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5HXB

Cereblon in complex with DDB1, CC-885, and GSPT1

Summary for 5HXB
Entry DOI10.2210/pdb5hxb/pdb
DescriptorEukaryotic peptide chain release factor GTP-binding subunit ERF3A, DNA damage-binding protein 1, Protein cereblon, ... (5 entities in total)
Functional Keywordse3, ligase, ubiquitin, dcaf, cereblon, ddb1, crl4, cullin, imid, gspt1, crbn
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm: Q16531 Q96SW2
Total number of polymer chains6
Total formula weight392392.25
Authors
Chamberlain, P.P.,Matyskiela, M.,Pagarigan, B. (deposition date: 2016-01-30, release date: 2016-06-29, Last modification date: 2023-09-27)
Primary citationMatyskiela, M.E.,Lu, G.,Ito, T.,Pagarigan, B.,Lu, C.C.,Miller, K.,Fang, W.,Wang, N.Y.,Nguyen, D.,Houston, J.,Carmel, G.,Tran, T.,Riley, M.,Nosaka, L.,Lander, G.C.,Gaidarova, S.,Xu, S.,Ruchelman, A.L.,Handa, H.,Carmichael, J.,Daniel, T.O.,Cathers, B.E.,Lopez-Girona, A.,Chamberlain, P.P.
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature, 535:252-257, 2016
Cited by
PubMed: 27338790
DOI: 10.1038/nature18611
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.6 Å)
Structure validation

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