5HXB
Cereblon in complex with DDB1, CC-885, and GSPT1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | X, A | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A | polymer | 199 | 21995.8 | 2 | UniProt (P15170) Pfam (PF03144) Pfam (PF22594) In PDB | Homo sapiens (Human) | eRF3a,G1 to S phase transition protein 1 homolog |
2 | Y, B | DNA damage-binding protein 1 | polymer | 1140 | 127097.5 | 2 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
3 | Z, C | Protein cereblon | polymer | 406 | 46596.6 | 2 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | Homo sapiens (Human) | |
4 | Z, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | Z, C | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea | non-polymer | 440.9 | 2 | Chemie (85C) |
Sequence modifications
X, A: 438 - 634 (UniProt: P15170)
Z, C: 40 - 442 (UniProt: Q96SW2)
PDB | External Database | Details |
---|---|---|
Gly 436 | - | expression tag |
Ser 437 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 37 | - | expression tag |
Ser 38 | - | expression tag |
Met 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 391379.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1012.6 | |
All* | Total formula weight | 392392.2 |