PDB: 2862 resultsInfo pagesStatus searchChemie searchBIRD

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7UY1	HUMAN PRMT5:MEP50 COMPLEX WITH MTA and Fragment 5 Bound Descriptor: 1,2-ETHANEDIOL, 3-methyl-1,5-naphthyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... Authors: Gunn, R.J. Deposit date: 2022-05-06 Release date: 2022-10-05 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
6NYA	Crystal Structure of ubiquitin E1 (Uba1) in complex with Ubc3 (Cdc34) and ubiquitin Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Olsen, S.K, Williams, K.M, Atkison, J.H. Deposit date: 2019-02-11 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.065 Å) Cite: Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34. Nat Commun, 10, 2019
7U30	PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1 Descriptor: (9R,10R,11S,12R,13R,14R)-4-amino-9-(3,4-difluorophenyl)-6,7,8,9,10,11,12,13-octahydro-10,13-epoxy[1,3]diazecino[1,2-e]purine-11,12-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... Authors: Palte, R.L. Deposit date: 2022-02-25 Release date: 2022-06-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity. Bioorg.Med.Chem., 66, 2022
7UOH	PRMT5/MEP50 crystal structure with MTA and an achiral, class 1, non-atropisomeric inhibitor bound Descriptor: (2M)-2-[(4M)-4-{4-(aminomethyl)-1-oxo-8-[(2R)-oxolan-2-yl]-1,2-dihydrophthalazin-6-yl}-1-methyl-1H-pyrazol-5-yl]-1-benzothiophene-3-carbonitrile, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... Authors: Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. Deposit date: 2022-04-12 Release date: 2022-08-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors. Bioorg.Med.Chem., 71, 2022
3COJ	Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1 Descriptor: Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein Authors: Shen, Y, Tong, L. Deposit date: 2008-03-28 Release date: 2008-05-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.21 Å) Cite: Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 Biochemistry, 47, 2008
5LZU	Structure of the mammalian ribosomal termination complex with accommodated eRF1 Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. Deposit date: 2016-10-02 Release date: 2016-11-30 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.75 Å) Cite: Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell, 167, 2016
6M7B	Structure of REV7-R124A complexed with SHLD3(37-73) Descriptor: Mitotic spindle assembly checkpoint protein MAD2B, Shieldin complex subunit 3 Authors: Ma, Y.Z, Li, Y, Wu, B.X, Huang, H.D. Deposit date: 2020-03-18 Release date: 2021-01-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structure of REV7-R124A complexed with SHLD3(37-73) To Be Published
6P5N	Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1 Descriptor: 18S rRNA, 28S rRNA, 5.8S rRNA, ... Authors: Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. Deposit date: 2019-05-30 Release date: 2019-09-25 Last modified: 2020-01-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
8I0Q	Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 (Local refine) Descriptor: Beta-arrestin-1, C-X-C chemokine receptor type 4, Fab30 Heavy Chain, ... Authors: Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K. Deposit date: 2023-01-11 Release date: 2023-05-17 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.45 Å) Cite: Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation. Mol.Cell, 83, 2023
7DCO	Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom Descriptor: BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ... Authors: Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. Deposit date: 2020-10-26 Release date: 2021-03-17 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
6P5K	Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3) Descriptor: 18S rRNA, 28S rRNA, 5.8S rRNA, ... Authors: Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. Deposit date: 2019-05-30 Release date: 2019-09-18 Last modified: 2020-01-08 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
6G5I	Cryo-EM structure of a late human pre-40S ribosomal subunit - State R Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2018-03-29 Release date: 2018-06-06 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
6G5H	Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2018-03-29 Release date: 2018-06-06 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
8FL0	Human nucleolar pre-60S ribosomal subunit (State H) Descriptor: 28S rRNA, 5S rRNA, 60S ribosomal protein L11, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.91 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
6G51	Cryo-EM structure of a late human pre-40S ribosomal subunit - State D Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2018-03-28 Release date: 2018-06-06 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
6G53	Cryo-EM structure of a late human pre-40S ribosomal subunit - State E Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Ameismeier, M, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2018-03-28 Release date: 2018-06-06 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Visualizing late states of human 40S ribosomal subunit maturation. Nature, 558, 2018
6P5I	Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1) Descriptor: 18S rRNA, 28S rRNA, 5.8S rRNA, ... Authors: Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. Deposit date: 2019-05-30 Release date: 2019-09-18 Last modified: 2020-02-26 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
6ICZ	Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... Authors: Zhang, X, Zhan, X, Yan, C, Shi, Y. Deposit date: 2018-09-07 Release date: 2019-03-13 Last modified: 2020-10-14 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
6CKC	Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity Descriptor: 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: Antonysamy, S. Deposit date: 2018-02-27 Release date: 2018-05-16 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med Chem Lett, 9, 2018
6R6P	Structure of XBP1u-paused ribosome nascent chain complex (rotated state) Descriptor: 18S rRNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2019-03-27 Release date: 2019-07-10 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
6R6G	Structure of XBP1u-paused ribosome nascent chain complex with SRP. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-27 Release date: 2019-07-10 Last modified: 2019-10-30 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
6P5J	Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2) Descriptor: 18S rRNA, 28S rRNA, 5.8S rRNA, ... Authors: Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. Deposit date: 2019-05-30 Release date: 2019-09-18 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
6R7Q	Structure of XBP1u-paused ribosome nascent chain complex with Sec61. Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. Deposit date: 2019-03-29 Release date: 2019-07-10 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
6R5Q	Structure of XBP1u-paused ribosome nascent chain complex (post-state) Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... Authors: Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. Deposit date: 2019-03-25 Release date: 2019-07-10 Last modified: 2019-10-30 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
8T1I	Atomic model of the mammalian Mediator complex with MED26 subunit Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ... Authors: Zhao, H, Asturias, F. Deposit date: 2023-06-02 Release date: 2024-06-12 Last modified: 2024-08-07 Method: ELECTRON MICROSCOPY (4.68 Å) Cite: An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II. Mol.Cell, 84, 2024

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