7U30

PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1

Summary for 7U30

Entry DOI	10.2210/pdb7u30/pdb
Descriptor	Protein arginine N-methyltransferase 5, Methylosome protein 50, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	prmt5, inhibitor, cyclonucleoside, methyl transferase, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	109461.47
Authors	Palte, R.L. (deposition date: 2022-02-25, release date: 2022-06-01, Last modification date: 2023-10-18)
Primary citation	Kawamura, S.,Palte, R.L.,Kim, H.Y.,Sauri, J.,Sondey, C.,Mansueto, M.S.,Altman, M.D.,Machacek, M.R. Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity. Bioorg.Med.Chem., 66:116820-116820, 2022 Cited by PubMed: 35594650 DOI: 10.1016/j.bmc.2022.116820 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation