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7U30

PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AProtein arginine N-methyltransferase 5polymer64573763.61UniProt (O14744)
Pfam (PF17285)
Pfam (PF05185)
Pfam (PF17286)
In PDB
Homo sapiens (human)72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs
2BMethylosome protein 50polymer32534796.91UniProt (Q9BQA1)
Pfam (PF00400)
In PDB
Homo sapiens (Human)MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50
3A, B1,2-ETHANEDIOLnon-polymer62.18Chemie (EDO)
4A(9R,10R,11S,12R,13R,14R)-4-amino-9-(3,4-difluorophenyl)-6,7,8,9,10,11,12,13-octahydro-10,13-epoxy[1,3]diazecino[1,2-e]purine-11,12-diolnon-polymer404.41Chemie (LB3)
5waterwater18.094Chemie (HOH)
Sequence modifications
A: 2 - 637 (UniProt: O14744)
PDBExternal DatabaseDetails
Met -7-initiating methionine
Asp -6-expression tag
Tyr -5-expression tag
Lys -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Asp 0-expression tag
Lys 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight108560.6
Non-Polymers*Number of molecules9
Total formula weight900.9
All*Total formula weight109461.5
*Water molecules are not included.

223532

PDB entries from 2024-08-07

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