6P5N

Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1

This is a large structure.

Summary for 6P5N

Related6P5I 6P5J 6P5K
EMDB information20255 20256 20257 20258
Descriptor28S rRNA, 5S rRNA, 5.8S rRNA, ... (82 entities in total)
Functional Keywordsisraeli acute paralysis virus, internal ribosome entry site, ires, small ribosomal subunit, 40s, large ribosomal subunit, 60s, 80s, ribosomes, eukaryotic release factor 1, erf1, ribosome
Biological sourceHomo sapiens (Human)
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Total number of polymer chains82
Total molecular weight3460272.5
Authors
Acosta-Reyes, F.J.,Neupane, R.,Frank, J.,Fernandez, I.S. (deposition date: 2019-05-30, release date: 2019-09-25)
Primary citation
Acosta-Reyes, F.J.,Neupane, R.,Frank, J.,Fernandez, I.S.
The Israeli Acute Paralysis Virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs
to be published,
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone2 0.6% 2.1% 0.44MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures