Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1

This is a large structure.

Summary for 6P5N

Related6P5I 6P5J 6P5K
EMDB information20255 20256 20257 20258
Descriptor28S rRNA, 5S rRNA, 5.8S rRNA, ... (82 entities in total)
Functional Keywordsisraeli acute paralysis virus, internal ribosome entry site, ires, small ribosomal subunit, 40s, large ribosomal subunit, 60s, 80s, ribosomes, eukaryotic release factor 1, erf1, ribosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains82
Total molecular weight3460272.5
Acosta-Reyes, F.J.,Neupane, R.,Frank, J.,Fernandez, I.S. (deposition date: 2019-05-30, release date: 2019-09-25, Last modification date: 2020-01-08)
Primary citation
Acosta-Reyes, F.,Neupane, R.,Frank, J.,Fernandez, I.S.
The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38:e102226-e102226, 2019
PubMed: 31609474 (PDB entries with the same primary citation)
DOI: 10.15252/embj.2019102226
MImport into Mendeley
Experimental method

Structure validation

Ramachandran outliersSidechain outliersRNA backbone 0.6% 2.1% 0.44MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
PDB entries from 2020-10-21