6CKC
Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity
Summary for 6CKC
Entry DOI | 10.2210/pdb6ckc/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 111506.93 |
Authors | Antonysamy, S. (deposition date: 2018-02-27, release date: 2018-05-16, Last modification date: 2024-03-13) |
Primary citation | Bonday, Z.Q.,Cortez, G.S.,Grogan, M.J.,Antonysamy, S.,Weichert, K.,Bocchinfuso, W.P.,Li, F.,Kennedy, S.,Li, B.,Mader, M.M.,Arrowsmith, C.H.,Brown, P.J.,Eram, M.S.,Szewczyk, M.M.,Barsyte-Lovejoy, D.,Vedadi, M.,Guccione, E.,Campbell, R.M. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med Chem Lett, 9:612-617, 2018 Cited by PubMed: 30034588DOI: 10.1021/acsmedchemlett.8b00014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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