6CKC

Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Protein arginine N-methyltransferase 5	polymer	650	74281.3	1	UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB	Homo sapiens (Human)	72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs
2	B	Methylosome protein 50	polymer	344	36883.3	1	UniProt (Q9BQA1) Pfam (PF00400) In PDB	Homo sapiens (Human)	MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50
3	A	7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	non-polymer		342.3	1	Chemie (F5J)
4		water	water		18.0	68	Chemie (HOH)

Sequence modifications

A: 1 - 637 (UniProt: O14744)

PDB	External Database	Details
Met -12	-	expression tag
Asp -11	-	expression tag
Tyr -10	-	expression tag
Lys -9	-	expression tag
Asp -8	-	expression tag
Asp -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Lys -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
Ala -1	-	expression tag
Thr 0	-	expression tag

B: 2 - 342 (UniProt: Q9BQA1)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag
Leu 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	111164.6
Non-Polymers*	Number of molecules	1
	Total formula weight	342.3
All*	Total formula weight	111506.9

*Water molecules are not included.