7UOH

PRMT5/MEP50 crystal structure with MTA and an achiral, class 1, non-atropisomeric inhibitor bound

Summary for 7UOH

• Entry DOI: 10.2210/pdb7uoh/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, (2M)-2-[(4M)-4-{4-(aminomethyl)-1-oxo-8-[(2R)-oxolan-2-yl]-1,2-dihydrophthalazin-6-yl}-1-methyl-1H-pyrazol-5-yl]-1-benzothiophene-3-carbonitrile, ... (5 entities in total)
• Functional Keywords: prmt5, mtap, mta, methyl transferase, collateral lethality, synthetic lethality, fragment-based lead discovery, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 112405.92

Authors

Gunn, R.J.,Thomas, N.C.,Lawson, J.D.,Ivetac, A.,Kulyk, S.,Smith, C.R.,Marx, M.A. (deposition date: 2022-04-12, release date: 2022-08-17, Last modification date: 2023-10-18)

• Primary citation: Smith, C.R.,Aranda, R.,Christensen, J.G.,Engstrom, L.D.,Gunn, R.J.,Ivetac, A.,Ketcham, J.M.,Kuehler, J.,David Lawson, J.,Marx, M.A.,Olson, P.,Thomas, N.C.,Wang, X.,Waters, L.M.,Kulyk, S.; Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.; Bioorg.Med.Chem., 71:116947-116947, 2022; PubMed: 35926325; DOI: 10.1016/j.bmc.2022.116947

Experimental method

X-RAY DIFFRACTION (2.7 Å)