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5WKT
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BU of 5wkt by Molmil
3.2-Angstrom In situ Mylar structure of bovine opsin at 100 K
Descriptor: Rhodopsin, SULFATE ION, Transducin Galpha peptide, ...
Authors:Broecker, J, Morizumi, T, Ou, W.-L, Ernst, O.P.
Deposit date:2017-07-25
Release date:2017-12-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.
Nat Protoc, 13, 2018
6TPK
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BU of 6tpk by Molmil
Crystal structure of the human oxytocin receptor
Descriptor: (3~{R},6~{R})-6-[(2~{S})-butan-2-yl]-3-(2,3-dihydro-1~{H}-inden-2-yl)-1-[(1~{R})-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxidanylidene-ethyl]piperazine-2,5-dione, CHOLESTEROL, DI(HYDROXYETHYL)ETHER, ...
Authors:Waltenspuehl, Y, Schoeppe, J, Ehrenmann, J, Kummer, L, Plueckthun, A.
Deposit date:2019-12-13
Release date:2020-08-05
Last modified:2020-09-02
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human oxytocin receptor.
Sci Adv, 6, 2020
7XTQ
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BU of 7xtq by Molmil
Cryo-EM structure of the R399-bound GPBAR-Gs complex
Descriptor: G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P.
Deposit date:2022-05-17
Release date:2022-07-06
Last modified:2022-08-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
4AMI
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BU of 4ami by Molmil
Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist bucindolol
Descriptor: 2-[(2S)-3-[[1-(1H-indol-3-yl)-2-methyl-propan-2-yl]amino]-2-oxidanyl-propoxy]benzenecarbonitrile, BETA-1 ADRENERGIC RECEPTOR, HEGA-10
Authors:Warne, T, Edwards, P.C, Leslie, A.G, Tate, C.G.
Deposit date:2012-03-11
Release date:2012-05-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
Structure, 20, 2012
5UVI
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BU of 5uvi by Molmil
Serial Millisecond Crystallography of Membrane and Soluble Protein Micro-crystals using Synchrotron Radiation
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ...
Authors:Martin-Garcia, J.M, Conrad, C.E, Nelson, G, Stander, N, Zatsepin, N.A, Zook, J, Zhu, L, Geiger, J, Chun, E, Kissick, D, Hilgart, M.C, Ogata, C, Ishchenko, A, Nagaratnam, N, Roy-Chowdhury, S, Coe, J, Subramanian, G, Schaffer, A, James, D, Ketawala, G, Venugopalan, N, Xu, S, Corcoran, S, Ferguson, D, Weierstall, U, Spence, J.C.H, Cherezov, V, Fromme, P, Fischetti, R.F, Liu, W.
Deposit date:2017-02-20
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation.
IUCrJ, 4, 2017
7U2L
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BU of 7u2l by Molmil
C5guano-uOR-Gi-scFv16
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Wang, H, Qu, Q, Skiniotis, G, Kobilka, B.
Deposit date:2022-02-24
Release date:2022-05-04
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure-based design of bitopic ligands for the μ-opioid receptor.
Nature, 613, 2023
6PT0
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BU of 6pt0 by Molmil
Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2
Descriptor: CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q.
Deposit date:2019-07-14
Release date:2020-02-12
Last modified:2020-03-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex.
Cell, 180, 2020
7Y14
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BU of 7y14 by Molmil
Cryo-EM structure of MrgD-Gi complex with beta-alanine (local)
Descriptor: BETA-ALANINE, PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D
Authors:Suzuki, S, Iida, M, Kawamoto, A, Oshima, A.
Deposit date:2022-06-06
Release date:2022-07-20
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
7XTA
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BU of 7xta by Molmil
Serotonin 4 (5-HT4) receptor-Gi-scFv16 complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
Deposit date:2022-05-16
Release date:2022-07-27
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XTC
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BU of 7xtc by Molmil
Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex
Descriptor: 3-(2-azanylethyl)-1H-indole-5-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
Deposit date:2022-05-16
Release date:2022-07-27
Last modified:2022-08-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
7XT9
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BU of 7xt9 by Molmil
Serotonin 4 (5-HT4) receptor-Gs complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E.
Deposit date:2022-05-16
Release date:2022-07-27
Last modified:2022-08-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
3OE6
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BU of 3oe6 by Molmil
Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t in I222 spacegroup
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate, C-X-C chemokine receptor type 4, ...
Authors:Wu, B, Mol, C.D, Han, G.W, Katritch, V, Chien, E.Y.T, Liu, W, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2010-08-12
Release date:2010-10-27
Last modified:2021-10-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
7LD3
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BU of 7ld3 by Molmil
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand
Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A.
Deposit date:2021-01-12
Release date:2021-09-08
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
Nature, 597, 2021
5D6L
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BU of 5d6l by Molmil
beta2AR-T4L - CIM
Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ...
Authors:Ma, P, Caffrey, M.
Deposit date:2015-08-12
Release date:2016-08-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The cubicon method for concentrating membrane proteins in the cubic mesophase.
Nat Protoc, 12, 2017
8GGM
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BU of 8ggm by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #5 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
7RMI
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BU of 7rmi by Molmil
SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A.
Deposit date:2021-07-27
Release date:2021-11-03
Last modified:2022-01-05
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
7W57
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BU of 7w57 by Molmil
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
Authors:You, C, Xu, H.E, Jiang, Y.
Deposit date:2021-11-29
Release date:2022-04-20
Last modified:2022-06-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
7W53
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BU of 7w53 by Molmil
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
Authors:You, C, Xu, H.E, Jiang, Y.
Deposit date:2021-11-29
Release date:2022-04-20
Last modified:2022-06-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
5XJM
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BU of 5xjm by Molmil
Complex structure of angiotensin II type 2 receptor with Fab
Descriptor: FabH, FabL, Sar1, ...
Authors:Asada, H, Horita, S, Shimamura, T, Iwata, S.
Deposit date:2017-05-02
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Nat. Struct. Mol. Biol., 25, 2018
7Y65
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BU of 7y65 by Molmil
Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein
Descriptor: C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
Deposit date:2022-06-18
Release date:2023-03-01
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
6JOD
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BU of 6jod by Molmil
Angiotensin II type 2 receptor with ligand
Descriptor: Angiotensin II, Heavy chain of 4A03Fab, Light chain of 4A03Fab, ...
Authors:Asada, H, Iwata, S, Hirata, K, Shimamura, T.
Deposit date:2019-03-20
Release date:2020-01-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
Structure, 28, 2020
8DPH
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BU of 8dph by Molmil
Cryo-EM structure of the 5HT2C receptor (VGV isoform) bound to lorcaserin
Descriptor: (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ...
Authors:Gumpper, R.H, Fay, J.F, Roth, B.L.
Deposit date:2022-07-15
Release date:2022-08-24
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.
Cell Rep, 40, 2022
7CKY
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BU of 7cky by Molmil
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
Descriptor: 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Yan, W, Shao, Z.
Deposit date:2020-07-20
Release date:2021-03-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
3SN6
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BU of 3sn6 by Molmil
Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Descriptor: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ...
Authors:Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
7LJD
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BU of 7ljd by Molmil
Allosteric modulator LY3154207 binding to dopamine-bound dopamine receptor 1 in complex with miniGs protein
Descriptor: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Zhuang, Y, Krumm, B, Zhang, H, Zhou, X.E, Wang, Y, Guo, J, Huang, X.-P, Liu, Y, Wang, L, Cheng, X, Jiang, Y, Jiang, H, Melcher, K, Zhang, C, Yi, W, Roth, B.L, Zhang, Y, Xu, H.E.
Deposit date:2021-01-28
Release date:2021-03-03
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor.
Cell Res., 31, 2021

222624

数据于2024-07-17公开中

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