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6ME4

XFEL crystal structure of human melatonin receptor MT1 in complex with 2-iodomelatonin

Summary for 6ME4
Entry DOI10.2210/pdb6me4/pdb
Descriptorchimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywordsgpcr, melatonin receptor type 1a (mt1), 2-iodomelatonin, membrane protein, xfel, lcp, pgs, circadian rhythm, jetlag
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains1
Total formula weight57153.74
Authors
Primary citationStauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Huang, X.P.,Gati, C.,Batyuk, A.,Slocum, S.T.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Shiriaeva, A.,Olsen, R.H.J.,Tribo, A.R.,Yous, S.,Stevens, R.C.,Weierstall, U.,Katritch, V.,Roth, B.L.,Liu, W.,Cherezov, V.
Structural basis of ligand recognition at the human MT1melatonin receptor.
Nature, 569:284-288, 2019
Cited by
PubMed: 31019306
DOI: 10.1038/s41586-019-1141-3
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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