6ME4
XFEL crystal structure of human melatonin receptor MT1 in complex with 2-iodomelatonin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase | polymer | 503 | 56597.4 | 1 | UniProt (P48039) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692) In PDB | Homo sapiens (Human) | Mel1a receptor,Glycogen synthase,Mel1a receptor |
| 2 | A | N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide | non-polymer | 358.2 | 1 | Chemie (ML2) | |||
| 3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 12 - 218 (UniProt: P48039)
A: 1001 - 1196 (UniProt: Q9V2J8)
A: 228 - 325 (UniProt: P48039)
| PDB | External Database | Details |
|---|---|---|
| Gly 10 | - | expression tag |
| Thr 11 | - | expression tag |
| Asn 73 | Asp 73 | engineered mutation |
| Phe 95 | Leu 95 | engineered mutation |
| Ala 104 | Gly 104 | engineered mutation |
| Trp 116 | Phe 116 | engineered mutation |
| Asp 124 | Asn 124 | engineered mutation |
| Leu 127 | Cys 127 | engineered mutation |
A: 228 - 325 (UniProt: P48039)
| PDB | External Database | Details |
|---|---|---|
| Phe 251 | Trp 251 | engineered mutation |
| Pro 292 | Ala 292 | engineered mutation |
| Asp 299 | Asn 299 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56597.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 556.4 | |
| All* | Total formula weight | 57153.7 |
