5JQH
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
Summary for 5JQH
Entry DOI | 10.2210/pdb5jqh/pdb |
Descriptor | Endolysin,Beta-2 adrenergic receptor, Nanobody60, Nb60, (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, ... (4 entities in total) |
Functional Keywords | gpcr, signaling, nanobody, allostery, signaling protein, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Enterobacteria phage T4 More |
Total number of polymer chains | 4 |
Total formula weight | 135830.68 |
Authors | Staus, D.P.,Strachan, R.T.,Manglik, A.,Pani, B.,Kahsai, A.W.,Kim, T.H.,Wingler, L.M.,Ahn, S.,Chatterjee, A.,Masoudi, A.,Kruse, A.C.,Pardon, E.,Steyaert, J.,Weis, W.I.,Prosser, R.S.,Kobilka, B.K.,Costa, T.,Lefkowitz, R.J. (deposition date: 2016-05-05, release date: 2016-07-13, Last modification date: 2023-09-27) |
Primary citation | Staus, D.P.,Strachan, R.T.,Manglik, A.,Pani, B.,Kahsai, A.W.,Kim, T.H.,Wingler, L.M.,Ahn, S.,Chatterjee, A.,Masoudi, A.,Kruse, A.C.,Pardon, E.,Steyaert, J.,Weis, W.I.,Prosser, R.S.,Kobilka, B.K.,Costa, T.,Lefkowitz, R.J. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature, 535:448-452, 2016 Cited by PubMed: 27409812DOI: 10.1038/nature18636 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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