5JQH

Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60

Summary for 5JQH

Entry DOI	10.2210/pdb5jqh/pdb
Descriptor	Endolysin,Beta-2 adrenergic receptor, Nanobody60, Nb60, (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, ... (4 entities in total)
Functional Keywords	gpcr, signaling, nanobody, allostery, signaling protein, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Enterobacteria phage T4 More
Total number of polymer chains	4
Total formula weight	135830.68
Authors	Staus, D.P.,Strachan, R.T.,Manglik, A.,Pani, B.,Kahsai, A.W.,Kim, T.H.,Wingler, L.M.,Ahn, S.,Chatterjee, A.,Masoudi, A.,Kruse, A.C.,Pardon, E.,Steyaert, J.,Weis, W.I.,Prosser, R.S.,Kobilka, B.K.,Costa, T.,Lefkowitz, R.J. (deposition date: 2016-05-05, release date: 2016-07-13, Last modification date: 2023-09-27)
Primary citation	Staus, D.P.,Strachan, R.T.,Manglik, A.,Pani, B.,Kahsai, A.W.,Kim, T.H.,Wingler, L.M.,Ahn, S.,Chatterjee, A.,Masoudi, A.,Kruse, A.C.,Pardon, E.,Steyaert, J.,Weis, W.I.,Prosser, R.S.,Kobilka, B.K.,Costa, T.,Lefkowitz, R.J. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature, 535:448-452, 2016 Cited by PubMed: 27409812 DOI: 10.1038/nature18636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation