5JQH
Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Endolysin,Beta-2 adrenergic receptor | polymer | 471 | 53699.3 | 2 | UniProt (P00720) UniProt (P07550) Pfam (PF00959) Pfam (PF00001) In PDB | Enterobacteria phage T4 | Lysis protein,Lysozyme,Muramidase,Beta-2 adrenoreceptor,Beta-2 adrenoceptor |
2 | D, C | Nanobody60, Nb60 | polymer | 125 | 13531.0 | 2 | Lama glama | ||
3 | A, B | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol | non-polymer | 298.4 | 2 | Chemie (CAU) | |||
4 | A, B | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) |
Sequence modifications
A, B: 867 - 1026 (UniProt: P00720)
A, B: 1030 - 1348 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Asp 852 | - | expression tag |
Tyr 853 | - | expression tag |
Lys 854 | - | expression tag |
Asp 855 | - | expression tag |
Asp 856 | - | expression tag |
Asp 857 | - | expression tag |
Asp 858 | - | expression tag |
Ala 859 | - | expression tag |
Glu 860 | - | expression tag |
Asn 861 | - | expression tag |
Leu 862 | - | expression tag |
Tyr 863 | - | expression tag |
Phe 864 | - | expression tag |
Gln 865 | - | expression tag |
Gly 866 | - | expression tag |
Gly 877 | Arg 12 | conflict |
Thr 919 | Cys 54 | engineered mutation |
Ala 962 | Cys 97 | engineered mutation |
Arg 1002 | Ile 137 | conflict |
Ala 1027 | - | linker |
Ala 1028 | - | linker |
Asp 1029 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 1096 | Met 96 | engineered mutation |
Thr 1098 | Met 98 | engineered mutation |
Glu 1187 | Asn 187 | engineered mutation |
- | Lys 235 | deletion |
- | Ser 236 | deletion |
- | Glu 237 | deletion |
- | Gly 238 | deletion |
- | Arg 239 | deletion |
- | Phe 240 | deletion |
- | His 241 | deletion |
- | Val 242 | deletion |
- | Gln 243 | deletion |
- | Asn 244 | deletion |
- | Leu 245 | deletion |
- | Ser 246 | deletion |
- | Gln 247 | deletion |
- | Val 248 | deletion |
- | Glu 249 | deletion |
- | Gln 250 | deletion |
- | Asp 251 | deletion |
- | Gly 252 | deletion |
- | Arg 253 | deletion |
- | Thr 254 | deletion |
- | Gly 255 | deletion |
- | His 256 | deletion |
- | Gly 257 | deletion |
- | Leu 258 | deletion |
- | Arg 259 | deletion |
- | Arg 260 | deletion |
Ile 1261 | Ser 261 | conflict |
Asp 1262 | Ser 262 | conflict |
Ala 1265 | Cys 265 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 134460.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1370.1 | |
All* | Total formula weight | 135830.7 |