4FFW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ffw by Molmil](/molmil-images/mine/4ffw) | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin | Descriptor: | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, Dipeptidyl peptidase 4, Fab heavy chain, ... | Authors: | Wang, Z, Sudom, A, Walker, N.P, Min, X. | Deposit date: | 2012-06-01 | Release date: | 2012-12-12 | Last modified: | 2021-05-19 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition To be published
|
|
3L95
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3l95 by Molmil](/molmil-images/mine/3l95) | |
4AQ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4aq4 by Molmil](/molmil-images/mine/4aq4) | substrate bound sn-glycerol-3-phosphate binding periplasmic protein ugpB from Escherichia coli | Descriptor: | CADMIUM ION, COBALT (II) ION, GLYCEROL, ... | Authors: | Wuttge, S, Bommer, M, Jaeger, F, Martins, B.M, Jacob, S, Licht, A, Scheffel, F, Dobbek, H, Schneider, E. | Deposit date: | 2012-04-13 | Release date: | 2012-10-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Determinants of Substrate Specificity and Biochemical Properties of the Sn-Glycerol-3-Phosphate ATP Binding Cassette Transporter (Ugpb-Aec(2) ) of Escherichia Coli. Mol.Microbiol., 86, 2012
|
|
4H0S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4h0s by Molmil](/molmil-images/mine/4h0s) | |
3DM0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dm0 by Molmil](/molmil-images/mine/3dm0) | Maltose Binding Protein fusion with RACK1 from A. thaliana | Descriptor: | 1,2-ETHANEDIOL, Maltose-binding periplasmic protein fused with RACK1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Ullah, H, Scappini, E.L, Moon, A.F, Williams, L.V, Armstrong, D.L, Pedersen, L.C. | Deposit date: | 2008-06-30 | Release date: | 2008-09-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana. Protein Sci., 17, 2008
|
|
4CY2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cy2 by Molmil](/molmil-images/mine/4cy2) | Crystal structure of the KANSL1-WDR5-KANSL2 complex. | Descriptor: | KAT8 REGULATORY NSL COMPLEX SUBUNIT 1, KAT8 REGULATORY NSL COMPLEX SUBUNIT 2, WD REPEAT-CONTAINING PROTEIN 5 | Authors: | Dias, J, Brettschneider, J, Cusack, S, Kadlec, J. | Deposit date: | 2014-04-09 | Release date: | 2014-05-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex. Genes Dev., 28, 2014
|
|
4CY3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cy3 by Molmil](/molmil-images/mine/4cy3) | Crystal structure of the NSL1-WDS complex. | Descriptor: | CG4699, ISOFORM D, GLYCEROL, ... | Authors: | Dias, J, Brettschneider, J, Cusack, S, Kadlec, J. | Deposit date: | 2014-04-10 | Release date: | 2014-05-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex. Genes Dev., 28, 2014
|
|
4CY5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cy5 by Molmil](/molmil-images/mine/4cy5) | Crystal structure of the NSL1-WDS-NSL2 complex. | Descriptor: | CG4699, ISOFORM D, DIM GAMMA-TUBULIN 1, ... | Authors: | Dias, J, Brettschneider, J, Cusack, S, Kadlec, J. | Deposit date: | 2014-04-10 | Release date: | 2014-05-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Analysis of the Kansl1/Wdr5/Kansl2 Complex Reveals that Wdr5 is Required for Efficient Assembly and Chromatin Targeting of the Nsl Complex. Genes Dev., 28, 2014
|
|
4HHQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hhq by Molmil](/molmil-images/mine/4hhq) | Serum paraoxonase-1 by directed evolution with the H115Q and H134Q mutations | Descriptor: | BROMIDE ION, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Moshe, B.-D, Grzegorz, W, Mikael, E, Israel, S, Joel, L.S, Dan, S.T. | Deposit date: | 2012-10-10 | Release date: | 2013-03-27 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. J.Mol.Biol., 425, 2013
|
|
4D6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4d6v by Molmil](/molmil-images/mine/4d6v) | Crystal structure of signal transducing protein | Descriptor: | G PROTEIN BETA SUBUNIT GIB2 | Authors: | Ero, R, Dimitrova, V.T, Chen, Y, Bu, W, Feng, S, Liu, T, Wang, P, Xue, C, Tan, S.M, Gao, Y.G. | Deposit date: | 2014-11-17 | Release date: | 2015-03-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of Gib2, a Signal-Transducing Protein Scaffold Associated with Ribosomes in Cryptococcus Neoformans. Sci.Rep., 5, 2015
|
|
4HSO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hso by Molmil](/molmil-images/mine/4hso) | Crystal structure of S213G variant DAH7PS from Neisseria meningitidis | Descriptor: | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... | Authors: | Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J. | Deposit date: | 2012-10-30 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine. Protein Sci., 22, 2013
|
|
3KRX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3krx by Molmil](/molmil-images/mine/3krx) | |
4BZK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bzk by Molmil](/molmil-images/mine/4bzk) | The structure of the COPII coat assembled on membranes | Descriptor: | Protein transport protein SEC13, Protein transport protein SEC31 | Authors: | Zanetti, G, Prinz, S, Daum, S, Meister, A, Schekman, R, Bacia, K, Briggs, J.A.G. | Deposit date: | 2013-07-26 | Release date: | 2013-09-18 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (40 Å) | Cite: | The Structure of the Copii Transport-Vesicle Coat Assembled on Membranes Elife, 2, 2013
|
|
4GM8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gm8 by Molmil](/molmil-images/mine/4gm8) | Crystal structure of human WD repeat domain 5 with compound MM-102 | Descriptor: | MM-102, WD repeat-containing protein 5 | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | Deposit date: | 2012-08-15 | Release date: | 2013-07-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
|
|
3AH8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ah8 by Molmil](/molmil-images/mine/3ah8) | Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Nishimura, A, Kitano, K, Takasaki, J, Taniguchi, M, Mizuno, N, Tago, K, Hakoshima, T, Itoh, H. | Deposit date: | 2010-04-20 | Release date: | 2010-07-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
4HHO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hho by Molmil](/molmil-images/mine/4hho) | Serum paraoxonase-1 by directed evolution with the H115W mutation | Descriptor: | BROMIDE ION, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Moshe, B.-D, Grzegorz, W, Mikael, E, Israel, S, Joel, L.S, Dan, S.T. | Deposit date: | 2012-10-10 | Release date: | 2013-03-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. J.Mol.Biol., 425, 2013
|
|
3EI2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ei2 by Molmil](/molmil-images/mine/3ei2) | Structure of hsDDB1-drDDB2 bound to a 16 bp abasic site containing DNA-duplex | Descriptor: | 5'-D(*DAP*DAP*DAP*DTP*DGP*DAP*DAP*DTP*(3DR)P*DAP*DAP*DGP*DCP*DAP*DGP*DG)-3', 5'-D(*DCP*DCP*DTP*DGP*DCP*DTP*DTP*DTP*DAP*DTP*DTP*DCP*DAP*DTP*DTP*DT)-3', DNA damage-binding protein 1, ... | Authors: | Scrima, A, Thoma, N.H. | Deposit date: | 2008-09-15 | Release date: | 2009-01-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell(Cambridge,Mass.), 135, 2008
|
|
3EMH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3emh by Molmil](/molmil-images/mine/3emh) | Structural basis of WDR5-MLL interaction | Descriptor: | Mixed-lineage leukemia protein 1, SULFATE ION, WD repeat-containing protein 5 | Authors: | Song, J.J, Kingston, R.E. | Deposit date: | 2008-09-24 | Release date: | 2008-10-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket. J.Biol.Chem., 283, 2008
|
|
3EE0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ee0 by Molmil](/molmil-images/mine/3ee0) | Crystal Structure of the W215A/E217A Mutant of Human Thrombin (space group P2(1)2(1)2(1)) | Descriptor: | Thrombin heavy chain, Thrombin light chain | Authors: | Gandhi, P.S, Page, M.J, Chen, Z, Bush-Pelc, L, Di Cera, E. | Deposit date: | 2008-09-03 | Release date: | 2009-07-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin To be Published
|
|
3EK9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ek9 by Molmil](/molmil-images/mine/3ek9) | SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding | Descriptor: | GLYCEROL, SPRY domain-containing SOCS box protein 2 | Authors: | Kuang, Z, Yao, S, Xu, Y, Garrett, T.J.P, Norton, R.S. | Deposit date: | 2008-09-19 | Release date: | 2009-02-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding. J.Mol.Biol., 386, 2009
|
|
4HSN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hsn by Molmil](/molmil-images/mine/4hsn) | Crystal structure of DAH7PS from Neisseria meningitidis | Descriptor: | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... | Authors: | Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J. | Deposit date: | 2012-10-30 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine. Protein Sci., 22, 2013
|
|
3EDX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3edx by Molmil](/molmil-images/mine/3edx) | Crystal structure of the W215A/E217A mutant of murine thrombin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Thrombin heavy chain, ... | Authors: | Gandhi, P.S, Page, M.J, Chen, Z, Bush-pelc, L, Di Cera, E. | Deposit date: | 2008-09-03 | Release date: | 2009-07-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular Basis for the Kinetic Differences of the W215A/E217A Mutant of Human and Murine Thrombin To be Published
|
|
4I79
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4i79 by Molmil](/molmil-images/mine/4i79) | Crystal structure of human NUP43 | Descriptor: | Nucleoporin Nup43, UNKNOWN ATOM OR ION, floating chain, ... | Authors: | Xu, C, Tempel, W, Li, Z, He, H, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2012-11-30 | Release date: | 2013-02-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of human nuclear pore complex component NUP43. Febs Lett., 589, 2015
|
|
4IA9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ia9 by Molmil](/molmil-images/mine/4ia9) | Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide | Descriptor: | 1,2-ETHANEDIOL, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... | Authors: | Dong, A, Dombrovski, L, Bolshan, Y, Getlik, M, Tempel, W, Kuznetsova, E, Wasney, G.A, Hajian, T, Poda, G, Nguyen, K.T, Schapira, M, Brown, P.J, Al-awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Smil, D, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-06 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett, 4, 2013
|
|
4HYJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hyj by Molmil](/molmil-images/mine/4hyj) | Crystal structure of Exiguobacterium sibiricum rhodopsin | Descriptor: | EICOSANE, RETINAL, Rhodopsin | Authors: | Gushchin, I, Chervakov, P, Kuzmichev, P, Popov, A, Round, E, Borshchevskiy, V, Dolgikh, D, Kirpichnikov, M, Petrovskaya, L, Chupin, V, Arseniev, A, Gordeliy, V. | Deposit date: | 2012-11-13 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural insights into the proton pumping by unusual proteorhodopsin from nonmarine bacteria. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|