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PDB: 18 results
3EK9
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BU of 3ek9 by Molmil
SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding
Descriptor: GLYCEROL, SPRY domain-containing SOCS box protein 2
Authors:Kuang, Z, Yao, S, Xu, Y, Garrett, T.J.P, Norton, R.S.
Deposit date:2008-09-19
Release date:2009-02-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.
J.Mol.Biol., 386, 2009
2H7T
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BU of 2h7t by Molmil
Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)
Descriptor: Insulin-like growth factor-binding protein 2
Authors:Kuang, Z.
Deposit date:2006-06-03
Release date:2007-04-24
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)
J.Mol.Biol., 364, 2006
2LO9
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BU of 2lo9 by Molmil
NMR solution structure of Mu-contoxin BuIIIB
Descriptor: Mu-conotoxin BuIIIB
Authors:Kuang, Z.
Deposit date:2012-01-20
Release date:2013-01-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mammalian neuronal sodium channel blocker mu-conotoxin BuIIIB has a structured N-terminus that influences potency.
Acs Chem.Biol., 8, 2013
2LOC
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BU of 2loc by Molmil
Conotoxin analogue [D-Ala2]BuIIIB
Descriptor: Mu-conotoxin BuIIIB
Authors:Kuang, Z.
Deposit date:2012-01-21
Release date:2013-01-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mammalian neuronal sodium channel blocker mu-conotoxin BuIIIB has a structured N-terminus that influences potency.
Acs Chem.Biol., 8, 2013
7EWF
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BU of 7ewf by Molmil
Selenomethionine-substituted structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1
Descriptor: 26S proteasome complex subunit SEM1, Cop9 signalosome complex subunit 12, Protein THP3
Authors:Kuang, Z, Niu, L.
Deposit date:2021-05-25
Release date:2022-09-07
Last modified:2023-04-05
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing.
Nucleic Acids Res., 50, 2022
7EWM
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BU of 7ewm by Molmil
Native crystal structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1
Descriptor: 26S proteasome complex subunit SEM1, Cop9 signalosome complex subunit 12, Protein THP3
Authors:Kuang, Z, Niu, L.
Deposit date:2021-05-25
Release date:2022-09-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing.
Nucleic Acids Res., 50, 2022
8JAT
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BU of 8jat by Molmil
Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans
Descriptor: 3-ketodihydrosphingosine reductase TSC10, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhao, P, Kuang, Z.
Deposit date:2023-05-07
Release date:2023-06-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans.
Biochem.Biophys.Res.Commun., 670, 2023
7C44
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BU of 7c44 by Molmil
Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a
Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4
Authors:Cheng, X.Y, Zhang, B.L, Kuang, Z.K, Yang, J, Li, Z.C, Yu, J.P, Zhao, Z.T, Cao, C.Z, Su, Z.D.
Deposit date:2020-05-15
Release date:2020-06-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the p53-binding domain of human MdmX protein in complex with Nutlin3a
To Be Published
7C3Q
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BU of 7c3q by Molmil
Human MdmX protein in complex with Nutlin3a
Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, DI(HYDROXYETHYL)ETHER, ...
Authors:Su, Z.D, Cheng, X.Y, Zhang, B.L, Kuang, Z.K, Yang, J, Li, Z.C, Yu, J.P, Zhao, Z.T, Cao, C.Z.
Deposit date:2020-05-13
Release date:2020-06-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Human MdmX protein in complex with Nutlin3a
To Be Published
7C3Y
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BU of 7c3y by Molmil
Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a
Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4
Authors:Su, Z.D, Cheng, X.Y, Zhang, B.L, Kuang, Z.K, Yang, J, Li, Z.C, Yu, J.P, Zhao, Z.T, Cao, C.Z.
Deposit date:2020-05-14
Release date:2020-06-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.632 Å)
Cite:Crystal structure of the N-terminal domain of human MdmX protein in complex with Nutlin3a
To Be Published
7EL4
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BU of 7el4 by Molmil
The crystal structure of p53p peptide fragment in complex with the N-terminal domain of MdmX
Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Cellular tumor antigen p53,Protein Mdm4, MAGNESIUM ION
Authors:Cheng, X.Y, Zhang, B.L, Li, Z.C, Kuang, Z.K, Su, Z.D.
Deposit date:2021-04-08
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The crystal structure of the N-terminal domain of MdmX in complex with p53p peptide fragment
To Be Published
5XN3
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BU of 5xn3 by Molmil
Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction
Descriptor: SPRY domain-containing SOCS box protein 2, cR8 peptide from NOS2
Authors:You, T, Kuang, Z.
Deposit date:2017-05-17
Release date:2017-06-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.
Biochem. Biophys. Res. Commun., 489, 2017
7CCB
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BU of 7ccb by Molmil
Crystal structure of the SPRY domain-containing protein 7 (SPRY7)
Descriptor: SPRY domain-containing protein 7
Authors:Yang, J, Kuang, Z.
Deposit date:2020-06-16
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structure of the SPRY domain-containing protein 7 reveals unique structural features.
Biochem.Biophys.Res.Commun., 531, 2020
6JKJ
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BU of 6jkj by Molmil
Crystal structure of human SPSB2 in the apo-state
Descriptor: SPRY domain-containing SOCS box protein 2
Authors:Luo, Y, Kuang, Z.
Deposit date:2019-03-01
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the SPRY domain of human SPSB2 in the apo state.
Acta Crystallogr.,Sect.F, 75, 2019
6JWN
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BU of 6jwn by Molmil
Crystal structure of the SPRY domain of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-04-21
Release date:2020-04-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structure of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction
To Be Published
6JWM
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BU of 6jwm by Molmil
Crystal structure of the SPRY domain of SPSB2 in complex with cR7, a potent cyclic peptide inhibitor of SPSB2-iNOS interaction
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-04-21
Release date:2020-04-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structure of SPSB2 in complex with cR7, a potent cyclic peptide inhibitor of SPSB2-iNOS interaction
To Be Published
6KEY
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BU of 6key by Molmil
Structural basis for the regulation of inducible nitric oxide synthase (iNOS) by the SPRY domain-containing SOCS box protein 2 (SPSB2)
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-07-05
Release date:2020-07-01
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase.
Nitric Oxide, 113-114, 2021
5ZXF
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BU of 5zxf by Molmil
The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a
Descriptor: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2
Authors:Cheng, X.Y, Su, Z.D, Pi, N, Cao, C.Z, Zhao, Z.T, Zhou, J.J, Chen, R, Kuang, Z.K, Huang, Y.Q.
Deposit date:2018-05-19
Release date:2018-08-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a
To Be Published

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