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8FY2
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BU of 8fy2 by Molmil
E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2)
Descriptor: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ...
Authors:Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K.
Deposit date:2023-01-25
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
8FTQ
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BU of 8ftq by Molmil
Crystal structure of hRpn13 Pru domain in complex with Ubiquitin and XL44
Descriptor: N-(3-{[(3R)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl}phenyl)-4-methoxybenzamide, Proteasomal ubiquitin receptor ADRM1, Ubiquitin
Authors:Walters, K.J, Lu, X, Chandravanshi, M.
Deposit date:2023-01-13
Release date:2024-03-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins.
Nat Commun, 15, 2024
8FY1
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BU of 8fy1 by Molmil
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2)
Descriptor: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ...
Authors:Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K.
Deposit date:2023-01-25
Release date:2024-04-10
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
8G1Q
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BU of 8g1q by Molmil
Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB
Descriptor: DI(HYDROXYETHYL)ETHER, Elongin-B, Elongin-C, ...
Authors:Ghimire Rijal, S, Wurz, R.P, Vaish, A.
Deposit date:2023-02-02
Release date:2023-07-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.73 Å)
Cite:Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation.
Nat Commun, 14, 2023
8G1P
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BU of 8g1p by Molmil
Co-crystal structure of Compound 11 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Descriptor: (2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ...
Authors:Ghimire Rijal, S, Wurz, R.P, Vaish, A.
Deposit date:2023-02-02
Release date:2023-07-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation.
Nat Commun, 14, 2023
8H38
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BU of 8h38 by Molmil
Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Hu, Y, Mao, Q, Chen, Z, Sun, L.
Deposit date:2022-10-08
Release date:2023-10-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
5XBO
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BU of 5xbo by Molmil
Lanthanoid tagging via an unnatural amino acid for protein structure characterization
Descriptor: Polyubiquitin-B, TERBIUM(III) ION, UV excision repair protein RAD23 homolog A
Authors:Jiang, W, Gu, X, Dong, X, Tang, C.
Deposit date:2017-03-21
Release date:2017-05-31
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Lanthanoid tagging via an unnatural amino acid for protein structure characterization
J. Biomol. NMR, 67, 2017
5XU8
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BU of 5xu8 by Molmil
Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine
Descriptor: 2-amino-1,9-dihydro-6H-purine-6-thione, CHLORIDE ION, SODIUM ION, ...
Authors:Chou, C.Y, Chuang, S.J.
Deposit date:2017-06-22
Release date:2018-02-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2
Sci Rep, 8, 2018
5JQS
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BU of 5jqs by Molmil
Crystal structure of deubiquitinase MINDY-1 in complex with Ubiquitin
Descriptor: 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, Protein FAM63A, ...
Authors:Abdul Rehman, S.A, Kulathu, Y.
Deposit date:2016-05-05
Release date:2016-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Mol.Cell, 63, 2016
5JP3
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BU of 5jp3 by Molmil
Structure of Xanthomonas campestris effector protein XopD bound to ubiquitin
Descriptor: Polyubiquitin-B, Xanthomonas outer protein D
Authors:Pruneda, J.N, Komander, D.
Deposit date:2016-05-03
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5JTJ
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BU of 5jtj by Molmil
USP7CD-CTP in complex with Ubiquitin
Descriptor: CALCIUM ION, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7,Ubiquitin carboxyl-terminal hydrolase 7
Authors:Murray, J.M, Rouge, L.
Deposit date:2016-05-09
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.321 Å)
Cite:Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation.
Structure, 24, 2016
5JTV
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BU of 5jtv by Molmil
USP7CD-UBL45 in complex with Ubiquitin
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Murray, J.M, Rouge, L.
Deposit date:2016-05-09
Release date:2016-10-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.312 Å)
Cite:Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation.
Structure, 24, 2016
5XVE
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BU of 5xve by Molmil
Crystal structure of human USP2 C276S mutant in complex with ubiquitin
Descriptor: Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin-40S ribosomal protein S27a, ZINC ION
Authors:Chou, C.Y, Tang, H.C.
Deposit date:2017-06-27
Release date:2018-02-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2
Sci Rep, 8, 2018
5U4P
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BU of 5u4p by Molmil
Protein-protein complex between 26S proteasome regulatory subunit RPN8, RPN11, and Ubiquitin S31
Descriptor: 26S proteasome regulatory subunit RPN11, 26S proteasome regulatory subunit RPN8, Ubiquitin-40S ribosomal protein S31, ...
Authors:Worden, E.J, Dong, K.C, Martin, A.
Deposit date:2016-12-05
Release date:2017-09-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
Mol. Cell, 67, 2017
5TXK
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BU of 5txk by Molmil
CRYSTAL STRUCTURE OF USP35 C450S IN COMPLEX WITH UBIQUITIN
Descriptor: 1,2-ETHANEDIOL, Polyubiquitin-B, SULFATE ION, ...
Authors:Bader, G, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2016-11-17
Release date:2018-05-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.
J. Cell. Sci., 131, 2018
5YDR
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BU of 5ydr by Molmil
Structure of DNMT1 RFTS domain in complex with ubiquitin
Descriptor: DNA (cytosine-5)-methyltransferase 1, PHOSPHATE ION, Polyubiquitin-B, ...
Authors:Qian, C.
Deposit date:2017-09-14
Release date:2018-02-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation.
Nucleic Acids Res., 46, 2018
5YT6
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BU of 5yt6 by Molmil
Crystal structure of TAX1BP1 UBZ2 in complex with mono-ubiquitin
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ...
Authors:Pan, L, Hu, S.
Deposit date:2017-11-17
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1.
J. Mol. Biol., 430, 2018
5V8T
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BU of 5v8t by Molmil
Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354
Descriptor: 2-{[3,5-bis(2-methoxyethoxy)benzene-1-carbonyl]amino}ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate, FORMIC ACID, MAGNESIUM ION, ...
Authors:Lorimer, D.D, Dranow, D.M, Seufert, F, Abendroth, J, Holzgrabe, U.
Deposit date:2017-03-22
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354
to be published
6ML1
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BU of 6ml1 by Molmil
Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S.
Deposit date:2018-09-26
Release date:2019-01-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6FGE
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BU of 6fge by Molmil
Crystal structure of human ZUFSP/ZUP1 in complex with ubiquitin
Descriptor: ACETATE ION, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kwasna, D, Abdul Rehman, S.A, Kulathu, Y.
Deposit date:2018-01-10
Release date:2018-04-04
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Mol. Cell, 70, 2018
5YIK
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BU of 5yik by Molmil
Structure of a Legionella effector with its substrate
Descriptor: SdeA, ubiquitin
Authors:Feng, Y, Dong, Y, Liu, Z.
Deposit date:2017-10-05
Release date:2018-05-30
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Structural basis of ubiquitin modification by the Legionella effector SdeA.
Nature, 557, 2018
6MUN
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BU of 6mun by Molmil
Structure of hRpn10 bound to UBQLN2 UBL
Descriptor: 26S proteasome non-ATPase regulatory subunit 4, Ubiquilin-2
Authors:Chen, X, Walters, K.J.
Deposit date:2018-10-23
Release date:2019-09-04
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.
J.Mol.Biol., 431, 2019
5L8W
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BU of 5l8w by Molmil
Structure of USP12-UB-PRG/UAF1
Descriptor: GLYCEROL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 12, ...
Authors:Dharadhar, S, Sixma, T.
Deposit date:2016-06-08
Release date:2016-09-28
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
J.Struct.Biol., 196, 2016
5KYC
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BU of 5kyc by Molmil
Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin (malonate bound)
Descriptor: GLYCEROL, MALONIC ACID, Polyubiquitin-B, ...
Authors:Rouge, L, Ozen, A.
Deposit date:2016-07-21
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.426 Å)
Cite:Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.
Structure, 26, 2018
5KYF
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BU of 5kyf by Molmil
Crystal structure of USP7 catalytic domain [L299A] mutant in complex with ubiquitin
Descriptor: GLYCEROL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Rouge, L, Ozen, A.
Deposit date:2016-07-21
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.
Structure, 26, 2018

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数据于2024-06-12公开中

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