8FY0

E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)

Summary for 8FY0

• Entry DOI: 10.2210/pdb8fy0/pdb
• Descriptor: von Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (7 entities in total)
• Functional Keywords: ternary complex, degrader, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 72763.98

Authors

Olsen, S.K.,Nayak, D.,Lv, D.,Yuan, Y.,Zhang, P.,Hu, W.,Lv, Z.,Sung, P.,Hromas, R.,Zheng, G.,Zhou, D. (deposition date: 2023-01-25, release date: 2024-04-10)

• Primary citation: Nayak, D.,Lv, D.,Yuan, Y.,Zhang, P.,Hu, W.,Nayak, A.,Ruben, E.A.,Lv, Z.,Sung, P.,Hromas, R.,Zheng, G.,Zhou, D.,Olsen, S.K.; Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.; Nat Commun, 15:2743-2743, 2024; PubMed: 38548768; DOI: 10.1038/s41467-024-46922-4

Experimental method

X-RAY DIFFRACTION (2.94 Å)