8FY0
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | von Hippel-Lindau disease tumor suppressor | polymer | 180 | 20729.5 | 1 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 2 | B (B) | Elongin-B | polymer | 118 | 13179.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C (C) | Elongin-C | polymer | 97 | 10914.5 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D (D) | Bcl-2-like protein 1 | polymer | 232 | 25977.5 | 1 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
| 5 | E (A) | CACODYLIC ACID | non-polymer | 138.0 | 1 | Chemie (CAD) | |||
| 6 | F, G (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | H (D) | N-[8-(4-{[(1R,3R,4S)-4-(4-chlorophenyl)-1-methyl-3-{[4-(4-{[4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-(trifluoromethanesulfonyl)benzene-1-sulfonyl]carbamoyl}phenyl)piperazin-1-yl]methyl}cyclohexyl]methyl}piperazin-1-yl)-8-oxooctanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide | non-polymer | 1640.5 | 1 | Chemie (YF8) |
Sequence modifications
A: 54 - 213 (UniProt: P40337)
C: 17 - 112 (UniProt: Q15369)
D: 1 - 212 (UniProt: Q07817)
| PDB | External Database | Details |
|---|---|---|
| Met 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Ser 36 | - | expression tag |
| Ser 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| Ser 44 | - | expression tag |
| Ser 45 | - | expression tag |
| Gly 46 | - | expression tag |
| Leu 47 | - | expression tag |
| Val 48 | - | expression tag |
| Pro 49 | - | expression tag |
| Arg 50 | - | expression tag |
| Gly 51 | - | expression tag |
| Ser 52 | - | expression tag |
| His 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 16 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70801.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1962.7 | |
| All* | Total formula weight | 72764.0 |
