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8FY0

E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)

Functional Information from GO Data
ChainGOidnamespacecontents
B0001222molecular_functiontranscription corepressor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005829cellular_componentcytosol
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006368biological_processtranscription elongation by RNA polymerase II
B0016567biological_processprotein ubiquitination
B0030891cellular_componentVCB complex
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0031466cellular_componentCul5-RING ubiquitin ligase complex
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0065003biological_processprotein-containing complex assembly
B0070449cellular_componentelongin complex
B0140958biological_processtarget-directed miRNA degradation
D0001541biological_processovarian follicle development
D0001701biological_processin utero embryonic development
D0001836biological_processrelease of cytochrome c from mitochondria
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0005783cellular_componentendoplasmic reticulum
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0006897biological_processendocytosis
D0006915biological_processapoptotic process
D0006950biological_processresponse to stress
D0007005biological_processmitochondrion organization
D0007281biological_processgerm cell development
D0007283biological_processspermatogenesis
D0008584biological_processmale gonad development
D0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
D0008637biological_processapoptotic mitochondrial changes
D0009314biological_processresponse to radiation
D0009566biological_processfertilization
D0009615biological_processresponse to virus
D0016020cellular_componentmembrane
D0019901molecular_functionprotein kinase binding
D0030672cellular_componentsynaptic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0031965cellular_componentnuclear membrane
D0031966cellular_componentmitochondrial membrane
D0032465biological_processregulation of cytokinesis
D0032946biological_processpositive regulation of mononuclear cell proliferation
D0034097biological_processresponse to cytokine
D0035234biological_processectopic germ cell programmed cell death
D0040008biological_processregulation of growth
D0042802molecular_functionidentical protein binding
D0043066biological_processnegative regulation of apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0044565biological_processdendritic cell proliferation
D0045202cellular_componentsynapse
D0046898biological_processresponse to cycloheximide
D0046902biological_processregulation of mitochondrial membrane permeability
D0050673biological_processepithelial cell proliferation
D0051093biological_processnegative regulation of developmental process
D0051400molecular_functionBH domain binding
D0051402biological_processneuron apoptotic process
D0051434molecular_functionBH3 domain binding
D0051607biological_processdefense response to virus
D0051881biological_processregulation of mitochondrial membrane potential
D0071230biological_processcellular response to amino acid stimulus
D0071312biological_processcellular response to alkaloid
D0071480biological_processcellular response to gamma radiation
D0071839biological_processapoptotic process in bone marrow cell
D0090201biological_processnegative regulation of release of cytochrome c from mitochondria
D0097048biological_processdendritic cell apoptotic process
D0097136cellular_componentBcl-2 family protein complex
D0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
D0097284biological_processhepatocyte apoptotic process
D1900118biological_processnegative regulation of execution phase of apoptosis
D1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
D1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
D1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D1903077biological_processnegative regulation of protein localization to plasma membrane
D2000242biological_processnegative regulation of reproductive process
D2000669biological_processnegative regulation of dendritic cell apoptotic process
D2001233biological_processregulation of apoptotic signaling pathway
D2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
D2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01080
Number of Residues19
DetailsBH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
ChainResidueDetails
DLEU130-GLY148

site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
DTRP181-VAL192

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
DVAL86-ARG100

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
DSER4-TRP24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by caspase-1
ChainResidueDetails
DASP61

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391
ChainResidueDetails
DSER49

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720
ChainResidueDetails
DSER62
BSER111

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PDB entries from 2024-07-24

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