8EWV

DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules

Summary for 8EWV

Entry DOI	10.2210/pdb8ewv/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	molecular glue, bifunctional compound, brd4, vcb, dna-encoded libraries, apoptosis
Biological source	Homo sapiens (human) More
Total number of polymer chains	24
Total formula weight	352458.72
Authors	Schreiber, S.L.,Shu, W.,Ma, X.,Michaud, G.,Bonazzi, S.,Berst, F. (deposition date: 2022-10-24, release date: 2023-10-04, Last modification date: 2024-02-14)
Primary citation	Mason, J.W.,Chow, Y.T.,Hudson, L.,Tutter, A.,Michaud, G.,Westphal, M.V.,Shu, W.,Ma, X.,Tan, Z.Y.,Coley, C.W.,Clemons, P.A.,Bonazzi, S.,Berst, F.,Briner, K.,Liu, S.,Zecri, F.J.,Schreiber, S.L. DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nat.Chem.Biol., 20:170-179, 2024 Cited by PubMed: 37919549 DOI: 10.1038/s41589-023-01458-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation