8EWV

DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001222	molecular_function	transcription corepressor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0016567	biological_process	protein ubiquitination
A	0030891	cellular_component	VCB complex
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0065003	biological_process	protein-containing complex assembly
A	0070449	cellular_component	elongin complex
A	0140958	biological_process	target-directed miRNA degradation
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0001222	molecular_function	transcription corepressor binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0016567	biological_process	protein ubiquitination
E	0030891	cellular_component	VCB complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0065003	biological_process	protein-containing complex assembly
E	0070449	cellular_component	elongin complex
E	0140958	biological_process	target-directed miRNA degradation
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0001222	molecular_function	transcription corepressor binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005829	cellular_component	cytosol
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0016567	biological_process	protein ubiquitination
I	0030891	cellular_component	VCB complex
I	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
I	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
I	0065003	biological_process	protein-containing complex assembly
I	0070449	cellular_component	elongin complex
I	0140958	biological_process	target-directed miRNA degradation
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0001222	molecular_function	transcription corepressor binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005829	cellular_component	cytosol
M	0006367	biological_process	transcription initiation at RNA polymerase II promoter
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0016567	biological_process	protein ubiquitination
M	0030891	cellular_component	VCB complex
M	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
M	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
M	0065003	biological_process	protein-containing complex assembly
M	0070449	cellular_component	elongin complex
M	0140958	biological_process	target-directed miRNA degradation
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0001222	molecular_function	transcription corepressor binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005829	cellular_component	cytosol
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0016567	biological_process	protein ubiquitination
Q	0030891	cellular_component	VCB complex
Q	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
Q	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Q	0065003	biological_process	protein-containing complex assembly
Q	0070449	cellular_component	elongin complex
Q	0140958	biological_process	target-directed miRNA degradation
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0001222	molecular_function	transcription corepressor binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0006367	biological_process	transcription initiation at RNA polymerase II promoter
U	0006368	biological_process	transcription elongation by RNA polymerase II
U	0016567	biological_process	protein ubiquitination
U	0030891	cellular_component	VCB complex
U	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
U	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
U	0065003	biological_process	protein-containing complex assembly
U	0070449	cellular_component	elongin complex
U	0140958	biological_process	target-directed miRNA degradation
V	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
D	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
D	ASN140
H	ASN140
L	ASN140
P	ASN140
T	ASN140
X	ASN140

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site_id	SWS_FT_FI2
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	LYS99
X	LYS99
E	THR84
H	LYS99
M	THR84
L	LYS99
U	THR84
P	LYS99
T	LYS99

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site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62869

Chain	Residue	Details
A	SER108
Q	SER111
U	SER108
U	SER111
A	SER111
E	SER108
E	SER111
I	SER108
I	SER111
M	SER108
M	SER111
Q	SER108

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