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7WVY
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Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2
Descriptor: Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-02-11
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVW
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BU of 7wvw by Molmil
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2
Descriptor: FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-02-11
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVU
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BU of 7wvu by Molmil
Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1
Descriptor: FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-02-11
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVV
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BU of 7wvv by Molmil
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2
Descriptor: FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-02-11
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVX
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BU of 7wvx by Molmil
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ...
Authors:Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-02-11
Release date:2022-04-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7T6B
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BU of 7t6b by Molmil
Structure of S1PR2-heterotrimeric G13 signaling complex
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, X, Chen, H.
Deposit date:2021-12-13
Release date:2022-04-06
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structure of S1PR2-heterotrimeric G 13 signaling complex.
Sci Adv, 8, 2022
7T6S
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BU of 7t6s by Molmil
Structure of the human FPR2-Gi complex with compound C43
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhuang, Y.W.
Deposit date:2021-12-14
Release date:2022-03-30
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Nat Commun, 13, 2022
7T6V
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BU of 7t6v by Molmil
Structure of the human FPR2-Gi complex with fMLFII
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhuang, Y.W.
Deposit date:2021-12-14
Release date:2022-03-30
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Nat Commun, 13, 2022
7T6U
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BU of 7t6u by Molmil
Structure of the human FPR2-Gi complex with CGEN-855A
Descriptor: B9-scFv, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhuang, Y.W.
Deposit date:2021-12-14
Release date:2022-03-30
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Nat Commun, 13, 2022
7T6T
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BU of 7t6t by Molmil
Structure of the human FPR1-Gi complex with fMLFII
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhuang, Y.W.
Deposit date:2021-12-14
Release date:2022-03-30
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Nat Commun, 13, 2022
7VLA
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BU of 7vla by Molmil
Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex
Descriptor: C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ...
Authors:Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H.
Deposit date:2021-10-02
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
7VL8
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BU of 7vl8 by Molmil
Cryo-EM structure of the Apo CCR1-Gi complex
Descriptor: C-C chemokine receptor type 1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H.
Deposit date:2021-10-02
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
7VL9
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BU of 7vl9 by Molmil
Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex
Descriptor: C-C chemokine receptor type 1, CCL15(26-92), CHOLESTEROL, ...
Authors:Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H.
Deposit date:2021-10-02
Release date:2022-03-23
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
7VKT
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BU of 7vkt by Molmil
cryo-EM structure of LTB4-bound BLT1 in complex with Gi protein
Descriptor: CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:He, Y, Wang, N.
Deposit date:2021-10-01
Release date:2022-03-09
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of leukotriene B4 receptor 1 activation.
Nat Commun, 13, 2022
7RYC
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BU of 7ryc by Molmil
Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Meyerowitz, J.G, Robertson, M.J, Skiniotis, G.
Deposit date:2021-08-24
Release date:2022-03-09
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The oxytocin signaling complex reveals a molecular switch for cation dependence.
Nat.Struct.Mol.Biol., 29, 2022
7T10
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BU of 7t10 by Molmil
CryoEM structure of somatostatin receptor 2 in complex with somatostatin-14 and Gi3
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ...
Authors:Robertson, M.J, Skinotis, G.
Deposit date:2021-11-30
Release date:2022-03-09
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Plasticity in ligand recognition at somatostatin receptors.
Nat.Struct.Mol.Biol., 29, 2022
7T11
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BU of 7t11 by Molmil
CryoEM structure of somatostatin receptor 2 in complex with Octreotide and Gi3.
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ...
Authors:Robertson, M.J, Skinotis, G.
Deposit date:2021-11-30
Release date:2022-03-09
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Plasticity in ligand recognition at somatostatin receptors.
Nat.Struct.Mol.Biol., 29, 2022
7VH0
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BU of 7vh0 by Molmil
MT2-remalteon-Gi complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Melatonin receptor type 1B, ...
Authors:Wang, Q.G, Lu, Q.Y.
Deposit date:2021-09-20
Release date:2022-03-02
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Nat Commun, 13, 2022
7VGY
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BU of 7vgy by Molmil
Melatonin receptor1-2-Iodomelatonin-Gicomplex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, Q.G, Lu, Q.Y.
Deposit date:2021-09-20
Release date:2022-03-02
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Nat Commun, 13, 2022
7VGZ
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BU of 7vgz by Molmil
MT1-remalteon-Gi complex
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wang, Q.G, Lu, Q.Y.
Deposit date:2021-09-20
Release date:2022-03-02
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Nat Commun, 13, 2022
7PYR
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BU of 7pyr by Molmil
Crystal structure of the adenosine A2A receptor (A2A-PSB1-bRIL) in complex with preladenant conjugate PSB-2115
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[2-[2-[2-[2-[2-[4-[4-[2-[7-azanyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]piperazin-1-yl]phenoxy]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]-~{N}-[5-[2,2-bis(fluoranyl)-4,6,10,12-tetramethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-8-yl]pentyl]ethanamide, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ...
Authors:Claff, T, Klapschinski, T.A, Tiruttani Subhramanyam, U.K, Vaassen, V.J, Schlegel, J.G, Vielmuth, C, Voss, J.H, Labahn, J, Muller, C.E.
Deposit date:2021-10-11
Release date:2022-03-02
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates.
Angew.Chem.Int.Ed.Engl., 61, 2022
7PX4
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BU of 7px4 by Molmil
Crystal structure of the adenosine A2A receptor (A2A-PSB1-bRIL) in complex with preladenant conjugate PSB-2113
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ...
Authors:Claff, T, Klapschinski, T.A, Tiruttani Subhramanyam, U.K, Vaassen, V.J, Schlegel, J.G, Vielmuth, C, Voss, J.H, Labahn, J, Muller, C.E.
Deposit date:2021-10-07
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A 2A Receptor with Preladenant Conjugates.
Angew.Chem.Int.Ed.Engl., 61, 2022
7VGX
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BU of 7vgx by Molmil
Neuropeptide Y Y1 Receptor (NPY1R) in Complex with G Protein and its endogeneous Peptide-Agonist Neuropeptide Y (NPY)
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Park, C, Kim, J, Jeong, H, Kang, H, Bang, I, Choi, H.-J.
Deposit date:2021-09-19
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of neuropeptide Y signaling through Y1 receptor
Nat Commun, 13, 2022
7JNI
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BU of 7jni by Molmil
Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FORMIC ACID, HEXANE-1,6-DIOL, ...
Authors:Cherezov, V, Shaye, H, Han, G.W.
Deposit date:2020-08-04
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma.
Proc.Natl.Acad.Sci.USA, 119, 2022
7TD0
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BU of 7td0 by Molmil
Lysophosphatidic acid receptor 1-Gi complex bound to LPA
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y.
Deposit date:2021-12-30
Release date:2022-02-09
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Nat Commun, 13, 2022

221716

数据于2024-06-26公开中

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