1IAI
 
 | | IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX | | Descriptor: | ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A), IDIOTYPIC FAB 730.1.4 (IGG1) OF VIRUS NEUTRALIZING ANTIBODY | | Authors: | Ban, N, Escobar, C, Garcia, R, Hasel, K, Day, J, Greenwood, A, McPherson, A. | | Deposit date: | 1993-12-28 | | Release date: | 1996-03-08 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of an idiotype-anti-idiotype Fab complex.
Proc.Natl.Acad.Sci.USA, 91, 1994
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7F9W
 | | CD25 in complex with Fab | | Descriptor: | Heavy chain of Fab, Interleukin-2 receptor subunit alpha, Light chain of Fab | | Authors: | Liu, C. | | Deposit date: | 2021-07-05 | | Release date: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity.
Sci Rep, 11, 2021
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6N5B
 | | Broadly protective antibodies directed to a subdominant influenza hemagglutinin epitope | | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, Hemagglutinin, antibody heavy chain, ... | | Authors: | Bajic, G, Maron, M.J, Schmidt, A.G. | | Deposit date: | 2018-11-21 | | Release date: | 2019-06-05 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.
Cell Host Microbe, 25, 2019
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5KVL
 | | Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4 | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Huxford, T, King, A, Fleming, J.K, Wojciak, J.M. | | Deposit date: | 2016-07-14 | | Release date: | 2017-05-24 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Humanized 10G4 anti-leukotriene C4 antibody Fab fragment in complex with leukotriene C4
To Be Published
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6VY2
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4OQT
 | | LINGO-1/Li81 Fab complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Li81 Fab, ... | | Authors: | Pepinsky, R.B, Arndt, J.W, Quan, C, Gao, Y, Quintero-Monzon, O, Lee, X, Mi, S. | | Deposit date: | 2014-02-10 | | Release date: | 2014-05-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.23 Å) | | Cite: | Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy.
J.Pharmacol.Exp.Ther., 350, 2014
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6ZFO
 | | Association of two complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, EY6A light chain, ... | | Authors: | Duyvesteyn, H.M.E, Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-06-17 | | Release date: | 2020-07-08 | | Last modified: | 2021-12-22 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
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6QKD
 | | CRYSTAL STRUCTURE OF vhh-based FAB-fragment of antibody BCD-085 | | Descriptor: | CHLORIDE ION, FAB HEAVY CHAIN, FAB LIGHT CHAIN, ... | | Authors: | Kostareva, O.S, Kolyadenko, I.A, Ulitin, A.B, Ekimova, V.M, Evdokimov, S.R, Garber, M.B, Tishchenko, T.V, Gabdulkhakov, A.G. | | Deposit date: | 2019-01-29 | | Release date: | 2019-07-24 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Fab Fragment of VHH-Based Antibody Netakimab: Crystal Structure and Modeling Interaction with Cytokine IL-17A
Crystals, 2019
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4NUY
 | | Crystal structure of EndoS, an endo-beta-N-acetyl-glucosaminidase from Streptococcus pyogenes | | Descriptor: | CALCIUM ION, Endo-beta-N-acetylglucosaminidase F2 | | Authors: | Trastoy, B, Guenther, S, Snyder, G.A, Sundberg, E.J. | | Deposit date: | 2013-12-04 | | Release date: | 2014-04-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.609 Å) | | Cite: | Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3G6J
 | | C3b in complex with a C3b specific Fab | | Descriptor: | CALCIUM ION, Complement C3 alpha chain, Complement C3 beta chain, ... | | Authors: | Wiesmann, C. | | Deposit date: | 2009-02-06 | | Release date: | 2009-03-10 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284, 2009
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8CIN
 | | BA.4/5-5 FAB IN COMPLEX WITH SARS-COV-2 BA.4 SPIKE GLYCOPROTEIN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA.4/5-5 fab HEAVY CHAIN, ... | | Authors: | Duyvesteyn, H.M.E, Ren, J, Stuart, D.I, Fry, E.E. | | Deposit date: | 2023-02-10 | | Release date: | 2024-02-21 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86.
Nat Commun, 15, 2024
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4LEX
 | | Unliganded crystal structure of mAb7 | | Descriptor: | FAB HEAVY CHAIN, FAB LIGHT CHAIN | | Authors: | Murray, J.M, Mukund, S. | | Deposit date: | 2013-06-26 | | Release date: | 2013-11-13 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
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6ZDG
 | | Association of three complexes of largely structurally disordered Spike ectodomain with bound EY6A Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EY6A heavy chain, EY6A light chain, ... | | Authors: | Duyvesteyn, H.M.E, Zhou, D, Zhao, Y, Fry, E.E, Ren, J, Stuart, D.I. | | Deposit date: | 2020-06-14 | | Release date: | 2020-07-29 | | Last modified: | 2021-12-22 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient.
Nat.Struct.Mol.Biol., 27, 2020
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4NUZ
 | | Crystal structure of a glycosynthase mutant (D233Q) of EndoS, an endo-beta-N-acetyl-glucosaminidase from Streptococcus pyogenes | | Descriptor: | CALCIUM ION, Endo-beta-N-acetylglucosaminidase F2 | | Authors: | Trastoy, B, Guenther, S, Snyder, G.A, Sundberg, E.J. | | Deposit date: | 2013-12-04 | | Release date: | 2014-04-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.905 Å) | | Cite: | Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.
Proc.Natl.Acad.Sci.USA, 111, 2014
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6MVL
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3KYK
 | | Crystal structure of li33 Igg1 Fab | | Descriptor: | Heavy Chain Li33 IgG1, Light Chain Li33 IgG1, SULFATE ION | | Authors: | Silvian, L.F, Pepinsky, R.B, Walus, L. | | Deposit date: | 2009-12-06 | | Release date: | 2010-03-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.
Protein Sci., 19, 2010
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3FCT
 | | MATURE METAL CHELATASE CATALYTIC ANTIBODY WITH HAPTEN | | Descriptor: | CADMIUM ION, CALCIUM ION, MAGNESIUM ION, ... | | Authors: | Romesberg, F.E, Santarsiero, B.D, Barnes, D, Yin, J, Spiller, B, Schultz, P.G, Stevens, R.C. | | Deposit date: | 1999-06-13 | | Release date: | 1999-06-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and kinetic evidence for strain in biological catalysis.
Biochemistry, 37, 1998
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3WJL
 | | Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor II-c, ... | | Authors: | Kadono, S, Mimoto, F, Katada, H, Igawa, T, Kuramochi, T, Muraoka, M, Wada, Y, Haraya, K, Miyazaki, T, Hattori, K. | | Deposit date: | 2013-10-11 | | Release date: | 2013-11-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Engineered antibody Fc variant with selectively enhanced Fc gamma RIIb binding over both Fc gamma RIIaR131 and Fc gamma RIIaH131.
Protein Eng.Des.Sel., 26, 2013
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4QNP
 | | Crystal structure of the 2009 pandemic H1N1 influenza virus neuraminidase with a neutralizing antibody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Wan, H.Q, Yang, H, Shore, D.A, Garten, R.J, Couzens, L, Gao, J, Jiang, L.L, Carney, P.J, Villanueva, J, Stevens, J, Eichelberger, M.C. | | Deposit date: | 2014-06-18 | | Release date: | 2015-02-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers.
Nat Commun, 6, 2015
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3J7E
 | | Electron cryo-microscopy of human papillomavirus 16 and H16.V5 Fab fragments | | Descriptor: | H16.V5 Fab heavy chain, H16.V5 Fab light chain | | Authors: | Lee, H, Brendle, S.A, Bywaters, S.M, Christensen, N.D, Hafenstein, S. | | Deposit date: | 2014-06-23 | | Release date: | 2014-11-26 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (13.6 Å) | | Cite: | A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.
J.Virol., 89, 2015
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3WJJ
 | | Crystal structure of IIb selective Fc variant, Fc(P238D), in complex with FcgRIIb | | Descriptor: | Ig gamma-1 chain C region, Low affinity immunoglobulin gamma Fc region receptor II-b, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Kadono, S, Mimoto, F, Katada, H, Igawa, T, Kuramochi, T, Muraoka, M, Wada, Y, Haraya, K, Miyazaki, T, Hattori, K. | | Deposit date: | 2013-10-10 | | Release date: | 2013-11-13 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Engineered antibody Fc variant with selectively enhanced Fc gamma RIIb binding over both Fc gamma RIIaR131 and Fc gamma RIIaH131.
Protein Eng.Des.Sel., 26, 2013
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8J1V
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8J1T
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5DYO
 | | Fab43.1 complex with flourescein | | Descriptor: | 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID, Fab 43.1 Heavy Chain, Fab 43.1 Light Chain, ... | | Authors: | Longenecker, K.L, Judge, R.A. | | Deposit date: | 2015-09-25 | | Release date: | 2016-01-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Three-dimensional structure, binding, and spectroscopic characteristics of the monoclonal antibody 43.1 directed to the carboxyphenyl moiety of fluorescein.
Biopolymers, 105, 2016
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4I3R
 | | Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... | | Authors: | Joyce, M.G, Biertumpfel, C, Nabel, G.J, Kwong, P.D. | | Deposit date: | 2012-11-26 | | Release date: | 2013-01-09 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.
J.Virol., 87, 2013
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