6MVL

Crystal structure of VISTA bound to a pH-selective antibody Fab fragment

Summary for 6MVL

• Entry DOI: 10.2210/pdb6mvl/pdb
• Descriptor: V-type immunoglobulin domain-containing suppressor of T-cell activation, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ... (6 entities in total)
• Functional Keywords: immunoglobulin, checkpoint, antibody, complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 68404.41

Authors

Critton, D.A. (deposition date: 2018-10-26, release date: 2019-10-23, Last modification date: 2020-07-29)

• Primary citation: Johnston, R.J.,Su, L.J.,Pinckney, J.,Critton, D.,Boyer, E.,Krishnakumar, A.,Corbett, M.,Rankin, A.L.,Dibella, R.,Campbell, L.,Martin, G.H.,Lemar, H.,Cayton, T.,Huang, R.Y.,Deng, X.,Nayeem, A.,Chen, H.,Ergel, B.,Rizzo, J.M.,Yamniuk, A.P.,Dutta, S.,Ngo, J.,Shorts, A.O.,Ramakrishnan, R.,Kozhich, A.,Holloway, J.,Fang, H.,Wang, Y.K.,Yang, Z.,Thiam, K.,Rakestraw, G.,Rajpal, A.,Sheppard, P.,Quigley, M.,Bahjat, K.S.,Korman, A.J.; VISTA is an acidic pH-selective ligand for PSGL-1.; Nature, 574:565-570, 2019; PubMed: 31645726; DOI: 10.1038/s41586-019-1674-5

Experimental method

X-RAY DIFFRACTION (1.61 Å)