8CIN
BA.4/5-5 FAB IN COMPLEX WITH SARS-COV-2 BA.4 SPIKE GLYCOPROTEIN
Summary for 8CIN
| Entry DOI | 10.2210/pdb8cin/pdb |
| Related | 8CBD 8CBE 8CBF |
| EMDB information | 16680 |
| Descriptor | Spike glycoprotein, BA.4/5-5 fab HEAVY CHAIN, BA.4/5-5 fab LIGHT CHAIN, ... (5 entities in total) |
| Functional Keywords | sars-cov2, spike, glycoprotein, coronavirus, antibody, fab, ba.4, ba.5, ba.4/5-5, cross-protective, omicron variant, vaccine, therapeutic, complex, neutralising, convalescent sera, viral protein, immune system |
| Biological source | Severe acute respiratory syndrome coronavirus 2 More |
| Total number of polymer chains | 9 |
| Total formula weight | 523600.00 |
| Authors | Duyvesteyn, H.M.E.,Ren, J.,Stuart, D.I.,Fry, E.E. (deposition date: 2023-02-10, release date: 2024-02-21, Last modification date: 2024-11-20) |
| Primary citation | Zhou, D.,Supasa, P.,Liu, C.,Dijokaite-Guraliuc, A.,Duyvesteyn, H.M.E.,Selvaraj, M.,Mentzer, A.J.,Das, R.,Dejnirattisai, W.,Temperton, N.,Klenerman, P.,Dunachie, S.J.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R. The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86. Nat Commun, 15:2734-2734, 2024 Cited by PubMed Abstract: Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for clinical use. Most potent antibodies bind to the receptor binding domain which has become heavily mutated. Here we study responses to a conserved epitope in sub-domain-1 (SD1) of spike which have become more prominent because of mutational escape from antibodies directed to the receptor binding domain. Some SD1 reactive mAbs show potent and broad neutralization of SARS-CoV-2 variants. We structurally map the dominant SD1 epitope and provide a mechanism of action by blocking interaction with ACE2. Mutations in SD1 have not been sustained to date, but one, E554K, leads to escape from mAbs. This mutation has now emerged in several sublineages including BA.2.86, reflecting selection pressure on the virus exerted by the increasing prominence of the anti-SD1 response. PubMed: 38548763DOI: 10.1038/s41467-024-46982-6 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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