C3b in complex with a C3b specific Fab

Summary for 3G6J

Related2ICF 2I07
DescriptorComplement C3 beta chain, Complement C3 alpha chain, Fab light chain, ... (5 entities in total)
Functional Keywordscomplement, c3b, fab, antibody:antigen, age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, glycoprotein, immune response, inflammatory response, innate immunity, phosphoprotein, secreted, thioester bond, immune system
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01024 P01024
Total number of polymer chains8
Total molecular weight445149.84
Wiesmann, C. (deposition date: 2009-02-06, release date: 2009-03-10, Last modification date: 2011-07-13)
Primary citation
Katschke, K.J.,Stawicki, S.,Yin, J.,Steffek, M.,Xi, H.,Sturgeon, L.,Hass, P.E.,Loyet, K.M.,Deforge, L.,Wu, Y.,van Lookeren Campagne, M.,Wiesmann, C.
Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284:10473-10479, 2009
PubMed: 19196712 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M809106200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28781.5%6.6%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report