3G6J

C3b in complex with a C3b specific Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
C	0004866	molecular_function	endopeptidase inhibitor activity
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 645

Chain	Residue
A	PRO505
A	ASP532
A	VAL533
A	ASP535

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 645

Chain	Residue
C	PRO505
C	ASP532
C	VAL533
C	ASP535

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
F	TYR194-HIS200
E	TYR192-HIS198

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site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM

Chain	Residue	Details
B	PRO985-MET993

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage; by factor I => ECO:0000255

Chain	Residue	Details
B	ARG932
D	ARG932

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Cleavage; by factor I

Chain	Residue	Details
B	ARG1281
B	ARG1298
D	ARG1281
D	ARG1298
C	SER16
C	SER48
C	SER275
C	SER281

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Coordinates Mg2+ for interaction with Complement factor B Bb fragment => ECO:0000269|PubMed:28264884, ECO:0000269|PubMed:31507604

Chain	Residue	Details
B	ASN1641
D	ASN1641

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
B	SER946
B	SER1299
B	SER1551
D	SER946
D	SER1299
D	SER1551

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150

Chain	Residue	Details
B	ASN917
D	ASN917

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
B	ASN1595
D	ASN1595

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site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln)

Chain	Residue	Details
B	CYS988
B	GLN991
D	CYS988
D	GLN991

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hzf

Chain	Residue	Details
B	GLN991
B	CYS988

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hzf

Chain	Residue	Details
D	GLN991
D	CYS988

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