6YCR
| Structure of human PD-L1 in complex with inhibitor | Descriptor: | FFIVIRDRVFR(CCS)G(NH2), Programmed cell death 1 ligand 1 | Authors: | Magiera-Mularz, K, Grudnik, P, Kuska, K, Holak, T.A, Dubin, G. | Deposit date: | 2020-03-18 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Macrocyclic Peptide Inhibitor of PD-1/PD-L1 Immune Checkpoint Adv. Ther., 2020
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6Y6C
| TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Single chain variable, Triggering receptor expressed on myeloid cells 2 | Authors: | Szykowska, A, Preger, C, Williams, E, Mukhopadhyay, S.M.M, McKinley, G, Gruslund, S, Wigren, E, Persson, H, Arrowsmith, C.H, Edwards, A, von Delft, F, Bountra, C, Davis, J.B, Di Daniel, E, Burgess-Brown, N, Bullock, A. | Deposit date: | 2020-02-26 | Release date: | 2021-02-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure, 29, 2021
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6VTT
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6VTU
| DH717.1 Fab monomer in complex with man9 glycan | Descriptor: | DH717.1 heavy chain, DH717.1 light chain, GLYCEROL, ... | Authors: | Fera, D, Bronkema, N. | Deposit date: | 2020-02-13 | Release date: | 2020-12-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies. Cell, 184, 2021
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6VSV
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6LXW
| Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal domain of SpsA | Descriptor: | Immunoglobulin J chain, Interleukin-2,Immunoglobulin heavy constant alpha 1, Polymeric immunoglobulin receptor, ... | Authors: | Wang, Y, Wang, G, Li, Y, Xiao, J. | Deposit date: | 2020-02-12 | Release date: | 2020-05-27 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Res., 30, 2020
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6VSJ
| Cryo-electron microscopy structure of mouse coronavirus spike protein complexed with its murine receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 1, Spike glycoprotein | Authors: | Shang, J, Wan, Y.S, Liu, C, Yount, B, Gully, K, Yang, Y, Auerbach, A, Peng, G.Q, Baric, R, Li, F. | Deposit date: | 2020-02-11 | Release date: | 2020-03-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. Plos Pathog., 16, 2020
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6LX3
| Cryo-EM structure of human secretory immunoglobulin A | Descriptor: | Immunoglobulin J chain, Interleukin-2,Immunoglobulin heavy constant alpha 1, Polymeric immunoglobulin receptor | Authors: | Wang, Y, Wang, G, Li, Y, Xiao, J. | Deposit date: | 2020-02-10 | Release date: | 2020-05-27 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin. Cell Res., 30, 2020
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6VRR
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6VRK
| Cryo-EM structure of the wild-type human serotonin transporter complexed with Br-paroxetine and 8B6 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | Authors: | Coleman, J.A, Navratna, V, Yang, D. | Deposit date: | 2020-02-07 | Release date: | 2020-03-11 | Last modified: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9, 2020
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6VRH
| Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | Authors: | Coleman, J.A, Navratna, V, Yang, D. | Deposit date: | 2020-02-07 | Release date: | 2020-03-11 | Last modified: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9, 2020
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6VRL
| Cryo-EM structure of the wild-type human serotonin transporter complexed with I-paroxetine and 8B6 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | Authors: | Coleman, J.A, Navratna, V, Yang, D. | Deposit date: | 2020-02-07 | Release date: | 2020-03-11 | Last modified: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9, 2020
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6VQN
| Co-crystal structure of human PD-L1 complexed with Compound A | Descriptor: | N,N'-(2,2'-dimethyl[1,1'-biphenyl]-3,3'-diyl)bis(5-{[(2-hydroxyethyl)amino]methyl}pyridine-2-carboxamide), Programmed cell death 1 ligand 1 | Authors: | White, A, Lakshminarasimhan, D, Leo, C, Suto, R.K. | Deposit date: | 2020-02-05 | Release date: | 2021-01-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun, 12, 2021
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6VPY
| I33M (I3.2 mutant from CH103 Lineage) | Descriptor: | CHLORIDE ION, GLYCEROL, I33M heavy chain, ... | Authors: | Fera, D, Zhou, J. | Deposit date: | 2020-02-04 | Release date: | 2020-07-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage. Front Immunol, 11, 2020
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6XY2
| Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Heavy chain, ... | Authors: | Gao, H, Zhou, A. | Deposit date: | 2020-01-29 | Release date: | 2020-12-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structure of CTLA-4 complexed with a pH-sensitive cancer immunotherapeutic antibody. Cell Discov, 6, 2020
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6LSA
| Complex structure of bovine herpesvirus 1 glycoprotein D and bovine nectin-1 IgV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein D, ... | Authors: | Yue, D, Chen, Z.J, Yang, F.L, Ye, F, Lin, S, Cheng, Y.W, Wang, J.C, Chen, Z.M, Lin, X, Yang, J, Chen, H, Zhang, Z.L, You, Y, Sun, H.L, Wen, A, Wang, L.L, Zheng, Y, Cao, Y, Li, Y.H, Lu, G.W. | Deposit date: | 2020-01-17 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor. Sci Adv, 6, 2020
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6TXZ
| FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 | Descriptor: | Fab H, Fab L, Hepatitis A virus cellular receptor 2 | Authors: | Musil, D, Sood, V. | Deposit date: | 2020-01-15 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Oncoimmunology, 9, 2020
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6V8Z
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6V8X
| VRC01 Bound BG505 F14 HIV-1 SOSIP Envelope Trimer Structure | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Henderson, R, Acharya, P. | Deposit date: | 2019-12-12 | Release date: | 2020-02-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements. Nat Commun, 11, 2020
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6V80
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6LHF
| Crystal structure of chicken cCD8aa/pBF2*15:01 | Descriptor: | Beta-2-microglobulin, CD8 alpha chain, MHC class I, ... | Authors: | Liu, Y.J, Xia, C. | Deposit date: | 2019-12-08 | Release date: | 2020-12-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Combination of CD8 alpha alpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gamma delta T Cells Response. Front Immunol, 11, 2020
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6LHG
| Crystal structure of chicken cCD8aa/pBF2*04:01 | Descriptor: | Beta-2-microglobulin, CD8 alpha chain, IE8 peptide, ... | Authors: | Liu, Y.J, Xia, C. | Deposit date: | 2019-12-08 | Release date: | 2020-12-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Combination of CD8 alpha alpha and Peptide-MHC-I in a Face-to-Face Mode Promotes Chicken gamma delta T Cells Response. Front Immunol, 11, 2020
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6V3P
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6L7Z
| Solution NMR structure of the N-terminal immunoglobulin variable domain of BTNL2 | Descriptor: | Butyrophilin-like protein 2 | Authors: | Basak, A.J, Lee, W, Samanta, D, De, S. | Deposit date: | 2019-11-03 | Release date: | 2020-10-14 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors. J.Mol.Biol., 432, 2020
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6UTA
| Crystal structure of Z004 iGL Fab in complex with ZIKV EDIII | Descriptor: | Env, Z004 iGL Fab heavy chain, Z004 iGL Fab light chain | Authors: | Esswein, S.R, Gristick, H.B, Keeffe, J.R, Bjorkman, P.J. | Deposit date: | 2019-10-29 | Release date: | 2020-04-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody. Proc.Natl.Acad.Sci.USA, 117, 2020
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