6V80

Crystal structure of human CD1d presenting alpha-Galactosylceramide in complex with NKT12 TCR and VHH nanobody 1D12

Summary for 6V80

• Entry DOI: 10.2210/pdb6v80/pdb
• Related: 6V7Y 6V7Z
• Descriptor: Antigen-presenting glycoprotein CD1d, Beta-2-microglobulin, T cell receptor alpha variable 10, nkt tcr alpha chain fusion, ... (8 entities in total)
• Functional Keywords: lipid, nanobody, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 233227.06

Authors

Shahine, A.,Rossjohn, J. (deposition date: 2019-12-10, release date: 2020-09-16, Last modification date: 2023-10-11)

• Primary citation: Shahine, A.,Rossjohn, J.; A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.; Nat Cancer, 2020; DOI: 10.1038/s43018-020-00111-6

Experimental method

X-RAY DIFFRACTION (3.53 Å)