6Y6C

TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4)

Summary for 6Y6C

• Entry DOI: 10.2210/pdb6y6c/pdb
• Descriptor: Triggering receptor expressed on myeloid cells 2, Single chain variable, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: scfv, complex, receptor, alzheimer's, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 98324.58

Authors

Szykowska, A.,Preger, C.,Williams, E.,Mukhopadhyay, S.M.M.,McKinley, G.,Gruslund, S.,Wigren, E.,Persson, H.,Arrowsmith, C.H.,Edwards, A.,von Delft, F.,Bountra, C.,Davis, J.B.,Di Daniel, E.,Burgess-Brown, N.,Bullock, A. (deposition date: 2020-02-26, release date: 2021-02-17, Last modification date: 2024-01-31)

• Primary citation: Szykowska, A.,Chen, Y.,Smith, T.B.,Preger, C.,Yang, J.,Qian, D.,Mukhopadhyay, S.M.,Wigren, E.,Neame, S.J.,Graslund, S.,Persson, H.,Atkinson, P.J.,Di Daniel, E.,Mead, E.,Wang, J.,Davis, J.B.,Burgess-Brown, N.A.,Bullock, A.N.; Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.; Structure, 29:1241-1252.e5, 2021; PubMed: 34233201; DOI: 10.1016/j.str.2021.06.010

Experimental method

X-RAY DIFFRACTION (2.26 Å)