6Y6C
TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4)
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 310 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | HIS19-SER174 | |
| B | HIS19-SER174 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29794134, ECO:0007744|PDB:6B8O |
| Chain | Residue | Details |
| A | HIS67 | |
| A | ASN68 | |
| A | ARG77 | |
| A | THR88 | |
| B | HIS67 | |
| B | ASN68 | |
| B | ARG77 | |
| B | THR88 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage of ectodomain => ECO:0000269|PubMed:28855300, ECO:0000269|PubMed:28855301, ECO:0000269|PubMed:28923481 |
| Chain | Residue | Details |
| A | HIS157 | |
| B | HIS157 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29794134, ECO:0007744|PDB:6B8O |
| Chain | Residue | Details |
| A | ASN20 | |
| B | ASN20 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:27995897, ECO:0000269|PubMed:29794134, ECO:0007744|PDB:5ELI, ECO:0007744|PDB:6B8O |
| Chain | Residue | Details |
| A | ASN79 | |
| B | ASN79 |
