6Y6C
TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Triggering receptor expressed on myeloid cells 2 | polymer | 202 | 22696.1 | 2 | UniProt (Q9NZC2) Pfam (PF07686) | Homo sapiens (Human) | TREM-2,Triggering receptor expressed on monocytes 2 |
| 2 | C, D (C, D) | Single chain variable | polymer | 245 | 26245.0 | 2 | Homo sapiens (Human) | ||
| 3 | E, F (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 375 | Chemie (HOH) |
Sequence modifications
A, B: 19 - 174 (UniProt: Q9NZC2)
| PDB | External Database | Details |
|---|---|---|
| Glu -6 | - | expression tag |
| Thr -5 | - | expression tag |
| Gly -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| His 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Val 6 | - | expression tag |
| Asp 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Thr 10 | - | expression tag |
| Glu 11 | - | expression tag |
| Asn 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Phe 15 | - | expression tag |
| Gln 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Met 18 | - | expression tag |
| Ser 175 | - | expression tag |
| Ser 176 | - | expression tag |
| Lys 177 | - | expression tag |
| Gly 178 | - | expression tag |
| Gly 179 | - | expression tag |
| Tyr 180 | - | expression tag |
| Gly 181 | - | expression tag |
| Leu 182 | - | expression tag |
| Asn 183 | - | expression tag |
| Asp 184 | - | expression tag |
| Ile 185 | - | expression tag |
| Phe 186 | - | expression tag |
| Glu 187 | - | expression tag |
| Ala 188 | - | expression tag |
| Gln 189 | - | expression tag |
| Lys 190 | - | expression tag |
| Ile 191 | - | expression tag |
| Glu 192 | - | expression tag |
| Trp 193 | - | expression tag |
| His 194 | - | expression tag |
| Glu 195 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 97882.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 98324.6 |
