6VQN

Co-crystal structure of human PD-L1 complexed with Compound A

Summary for 6VQN

• Entry DOI: 10.2210/pdb6vqn/pdb
• Descriptor: Programmed cell death 1 ligand 1, N,N'-(2,2'-dimethyl[1,1'-biphenyl]-3,3'-diyl)bis(5-{[(2-hydroxyethyl)amino]methyl}pyridine-2-carboxamide) (3 entities in total)
• Functional Keywords: complex, cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 45567.20

Authors

White, A.,Lakshminarasimhan, D.,Leo, C.,Suto, R.K. (deposition date: 2020-02-05, release date: 2021-01-20, Last modification date: 2023-10-11)

• Primary citation: Park, J.J.,Thi, E.P.,Carpio, V.H.,Bi, Y.,Cole, A.G.,Dorsey, B.D.,Fan, K.,Harasym, T.,Iott, C.L.,Kadhim, S.,Kim, J.H.,Lee, A.C.H.,Nguyen, D.,Paratala, B.S.,Qiu, R.,White, A.,Lakshminarasimhan, D.,Leo, C.,Suto, R.K.,Rijnbrand, R.,Tang, S.,Sofia, M.J.,Moore, C.B.; Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1.; Nat Commun, 12:1222-1222, 2021; PubMed: 33619272; DOI: 10.1038/s41467-021-21410-1

Experimental method

X-RAY DIFFRACTION (2.49 Å)