6VQN
Co-crystal structure of human PD-L1 complexed with Compound A
Summary for 6VQN
Entry DOI | 10.2210/pdb6vqn/pdb |
Descriptor | Programmed cell death 1 ligand 1, N,N'-(2,2'-dimethyl[1,1'-biphenyl]-3,3'-diyl)bis(5-{[(2-hydroxyethyl)amino]methyl}pyridine-2-carboxamide) (3 entities in total) |
Functional Keywords | complex, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 45567.20 |
Authors | White, A.,Lakshminarasimhan, D.,Leo, C.,Suto, R.K. (deposition date: 2020-02-05, release date: 2021-01-20, Last modification date: 2023-10-11) |
Primary citation | Park, J.J.,Thi, E.P.,Carpio, V.H.,Bi, Y.,Cole, A.G.,Dorsey, B.D.,Fan, K.,Harasym, T.,Iott, C.L.,Kadhim, S.,Kim, J.H.,Lee, A.C.H.,Nguyen, D.,Paratala, B.S.,Qiu, R.,White, A.,Lakshminarasimhan, D.,Leo, C.,Suto, R.K.,Rijnbrand, R.,Tang, S.,Sofia, M.J.,Moore, C.B. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun, 12:1222-1222, 2021 Cited by PubMed: 33619272DOI: 10.1038/s41467-021-21410-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.49 Å) |
Structure validation
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