8J21
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![BU of 8j21 by Molmil](/molmil-images/mine/8j21) | Cryo-EM structure of FFAR3 complex bound with butyrate acid | Descriptor: | Free fatty acid receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | Deposit date: | 2023-04-14 | Release date: | 2024-01-24 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3. Cell Res., 34, 2024
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8T3V
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![BU of 8t3v by Molmil](/molmil-images/mine/8t3v) | Cryo-EM structure of the DHA bound FFA1-Gq complex | Descriptor: | CHOLESTEROL, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | Deposit date: | 2023-06-07 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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8T3O
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![BU of 8t3o by Molmil](/molmil-images/mine/8t3o) | Cryo-EM structure of the TUG-891 bound FFA4-Gq complex | Descriptor: | (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, ... | Authors: | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | Deposit date: | 2023-06-07 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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8WDT
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![BU of 8wdt by Molmil](/molmil-images/mine/8wdt) | Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue) | Descriptor: | (2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide, Adenosine receptor A2a, Antibody Fab fragment heavy chain, ... | Authors: | Araya, T, Asada, H, Iwata, S, Im, D.H. | Deposit date: | 2023-09-16 | Release date: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.34 Å) | Cite: | Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A 2A receptor. Biochem.Biophys.Res.Commun., 695, 2023
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8X5X
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8X64
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![BU of 8x64 by Molmil](/molmil-images/mine/8x64) | |
8X63
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![BU of 8x63 by Molmil](/molmil-images/mine/8x63) | |
8X5Y
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8J6J
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![BU of 8j6j by Molmil](/molmil-images/mine/8j6j) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073 | Descriptor: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | Deposit date: | 2023-04-26 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8JGF
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![BU of 8jgf by Molmil](/molmil-images/mine/8jgf) | CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 | Descriptor: | BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | Deposit date: | 2023-05-20 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
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8JGG
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![BU of 8jgg by Molmil](/molmil-images/mine/8jgg) | CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22 | Descriptor: | BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Sun, J.P, Xu, H.E, Ynag, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | Deposit date: | 2023-05-20 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
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8JGB
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![BU of 8jgb by Molmil](/molmil-images/mine/8jgb) | CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2 | Descriptor: | Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | Deposit date: | 2023-05-20 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
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8GDA
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![BU of 8gda by Molmil](/molmil-images/mine/8gda) | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | Descriptor: | (2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Shenming, H, Mengyao, X, Lei, L, Jiangqian, M, Sheng, C, Jinpeng, S. | Deposit date: | 2023-03-03 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GDB
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![BU of 8gdb by Molmil](/molmil-images/mine/8gdb) | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Shenming, H, Mengyao, X, Lei, L, Jianqiang, M, Jinpeng, S. | Deposit date: | 2023-03-03 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GDC
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![BU of 8gdc by Molmil](/molmil-images/mine/8gdc) | Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Shenming, H, Mengyao, X, Lei, L, Yang, D, Shiyi, G, Jinpeng, S. | Deposit date: | 2023-03-03 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GD9
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![BU of 8gd9 by Molmil](/molmil-images/mine/8gd9) | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | Descriptor: | 4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Shenming, H, Mengyao, X, Lei, L, Yang, D, Sheng, C, Jinpeng, S. | Deposit date: | 2023-03-03 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8UHB
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![BU of 8uhb by Molmil](/molmil-images/mine/8uhb) | Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex | Descriptor: | (2R,4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zilberg, G, Warren, A.L, Parpounas, A.K, Wacker, D. | Deposit date: | 2023-10-08 | Release date: | 2024-01-10 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Molecular basis of human trace amine-associated receptor 1 activation. Nat Commun, 15, 2024
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8IJA
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![BU of 8ija by Molmil](/molmil-images/mine/8ija) | Cryo-EM structure of human HCAR2-Gi complex with niacin | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-26 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8IJD
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![BU of 8ijd by Molmil](/molmil-images/mine/8ijd) | Cryo-EM structure of human HCAR2-Gi complex with MK-6892 | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-27 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8IJ3
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![BU of 8ij3 by Molmil](/molmil-images/mine/8ij3) | Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-24 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8IJB
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![BU of 8ijb by Molmil](/molmil-images/mine/8ijb) | Cryo-EM structure of human HCAR2-Gi complex with acipimox | Descriptor: | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-27 | Release date: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8GCM
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![BU of 8gcm by Molmil](/molmil-images/mine/8gcm) | Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein | Descriptor: | (5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. | Deposit date: | 2023-03-02 | Release date: | 2024-01-03 | Last modified: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GCP
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![BU of 8gcp by Molmil](/molmil-images/mine/8gcp) | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | Descriptor: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. | Deposit date: | 2023-03-02 | Release date: | 2024-01-03 | Last modified: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8W8Q
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![BU of 8w8q by Molmil](/molmil-images/mine/8w8q) | Cryo-EM structure of the GPR101-Gs complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Sun, J.P, Gao, N, Yu, X, Wang, G.P, Yang, F, Wang, J.Y, Yang, Z, Guan, Y. | Deposit date: | 2023-09-04 | Release date: | 2024-01-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
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8W8S
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![BU of 8w8s by Molmil](/molmil-images/mine/8w8s) | Cryo-EM structure of the AA14-bound GPR101 complex | Descriptor: | 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Probable G-protein coupled receptor 101 | Authors: | Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. | Deposit date: | 2023-09-04 | Release date: | 2024-01-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
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