4O4R
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![BU of 4o4r by Molmil](/molmil-images/mine/4o4r) | Murine Norovirus RdRp in complex with PPNDS | Descriptor: | 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, RNA-dependent-RNA-polymerase, SULFATE ION | Authors: | Croci, R, Tarantino, D, Milani, M, Pezzullo, M, Bolognesi, M, Mastrangelo, E. | Deposit date: | 2013-12-19 | Release date: | 2014-11-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. Febs Lett., 588, 2014
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4NRU
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![BU of 4nru by Molmil](/molmil-images/mine/4nru) | Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative | Descriptor: | 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, MAGNESIUM ION, RNA dependent RNA polymerase | Authors: | Milani, M, Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Bolognesi, M. | Deposit date: | 2013-11-27 | Release date: | 2014-10-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. Plos One, 9, 2014
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7THM
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![BU of 7thm by Molmil](/molmil-images/mine/7thm) | SARS-CoV-2 nsp12/7/8 complex with a native N-terminus nsp9 | Descriptor: | MANGANESE (II) ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Osinski, A, Tagliabracci, V.S, Chen, Z, Li, Y. | Deposit date: | 2022-01-11 | Release date: | 2022-03-16 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | The mechanism of RNA capping by SARS-CoV-2. Nature, 609, 2022
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7OZV
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![BU of 7ozv by Molmil](/molmil-images/mine/7ozv) | SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G | Descriptor: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | Authors: | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | Deposit date: | 2021-06-28 | Release date: | 2021-08-18 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat.Struct.Mol.Biol., 28, 2021
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7OZU
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![BU of 7ozu by Molmil](/molmil-images/mine/7ozu) | SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with A | Descriptor: | Non-structural protein 7, Non-structural protein 8, Product RNA, ... | Authors: | Kabinger, F, Stiller, C, Schmitzova, J, Dienemann, C, Kokic, G, Hillen, H.S, Hoebartner, C, Cramer, P. | Deposit date: | 2021-06-28 | Release date: | 2021-08-18 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat.Struct.Mol.Biol., 28, 2021
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7OYG
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![BU of 7oyg by Molmil](/molmil-images/mine/7oyg) | Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase | Descriptor: | RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase (nsp12), ... | Authors: | Jochheim, F.A, Tegunov, D, Hillen, H.S, Schmitzova, J, Kokic, G, Dienemann, C, Cramer, P. | Deposit date: | 2021-06-24 | Release date: | 2021-08-25 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | The structure of a dimeric form of SARS-CoV-2 polymerase Communications Biology, 4, 2021
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6XQB
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![BU of 6xqb by Molmil](/molmil-images/mine/6xqb) | SARS-CoV-2 RdRp/RNA complex | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Liu, B, Shi, W, Yang, Y. | Deposit date: | 2020-07-09 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution To Be Published
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6XEZ
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![BU of 6xez by Molmil](/molmil-images/mine/6xez) | Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | Authors: | Chen, J, Malone, B, Llewellyn, E.C, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-06-14 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell, 182, 2020
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6YYT
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![BU of 6yyt by Molmil](/molmil-images/mine/6yyt) | Structure of replicating SARS-CoV-2 polymerase | Descriptor: | RNA product, ZINC ION, nsp12, ... | Authors: | Hillen, H.S, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P. | Deposit date: | 2020-05-06 | Release date: | 2020-05-13 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of replicating SARS-CoV-2 polymerase. Nature, 584, 2020
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8SQ9
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![BU of 8sq9 by Molmil](/molmil-images/mine/8sq9) | SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Small, G.I, Darst, S.A, Campbell, E.A. | Deposit date: | 2023-05-04 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
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8SQK
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![BU of 8sqk by Molmil](/molmil-images/mine/8sqk) | SARS-CoV-2 replication-transcription complex bound to RNA-nsp9 and GDP-betaS, as a pre-catalytic deRNAylation/mRNA capping intermediate | Descriptor: | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Small, G.I, Darst, S.A, Campbell, E.A. | Deposit date: | 2023-05-04 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
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8SQJ
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![BU of 8sqj by Molmil](/molmil-images/mine/8sqj) | SARS-CoV-2 replication-transcription complex bound to RNA-nsp9, as a noncatalytic RNA-nsp9 binding mode | Descriptor: | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Small, G.I, Darst, S.A, Campbell, E.A. | Deposit date: | 2023-05-04 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
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8URB
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![BU of 8urb by Molmil](/molmil-images/mine/8urb) | |
7KRN
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![BU of 7krn by Molmil](/molmil-images/mine/7krn) | Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | Authors: | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-11-20 | Release date: | 2021-04-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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7KRP
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![BU of 7krp by Molmil](/molmil-images/mine/7krp) | Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHAPSO, MAGNESIUM ION, ... | Authors: | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-11-20 | Release date: | 2021-04-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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7KRO
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![BU of 7kro by Molmil](/molmil-images/mine/7kro) | Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CHAPSO, ... | Authors: | Chen, J, Malone, B, Campbell, E.A, Darst, S.A. | Deposit date: | 2020-11-20 | Release date: | 2021-04-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex. Proc.Natl.Acad.Sci.USA, 118, 2021
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7L1F
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![BU of 7l1f by Molmil](/molmil-images/mine/7l1f) | SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate | Descriptor: | Non-structural protein 7, Non-structural protein 8, RNA (5'-R(P*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*G)-3'), ... | Authors: | Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2020-12-14 | Release date: | 2021-02-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Mol.Cell, 81, 2021
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8GW1
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![BU of 8gw1 by Molmil](/molmil-images/mine/8gw1) | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | Descriptor: | Helicase, MANGANESE (II) ION, Non-structural protein 7, ... | Authors: | Yan, L, Rao, Z, Lou, Z. | Deposit date: | 2022-09-16 | Release date: | 2023-10-25 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GY6
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![BU of 8gy6 by Molmil](/molmil-images/mine/8gy6) | |
8GWM
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![BU of 8gwm by Molmil](/molmil-images/mine/8gwm) | SARS-CoV-2 E-RTC bound with MMP-nsp9 and GMPPNP | Descriptor: | 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), Helicase, Non-structural protein 7, ... | Authors: | Yan, L.M, Rao, Z.H, Lou, Z.Y. | Deposit date: | 2022-09-17 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWK
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![BU of 8gwk by Molmil](/molmil-images/mine/8gwk) | SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP | Descriptor: | Helicase, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | Deposit date: | 2022-09-17 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.72 Å) | Cite: | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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7UO9
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![BU of 7uo9 by Molmil](/molmil-images/mine/7uo9) | SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UO4
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![BU of 7uo4 by Molmil](/molmil-images/mine/7uo4) | SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UOB
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![BU of 7uob by Molmil](/molmil-images/mine/7uob) | SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state | Descriptor: | 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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7UO7
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![BU of 7uo7 by Molmil](/molmil-images/mine/7uo7) | SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. | Deposit date: | 2022-04-12 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
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